Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1059832..1060430 Replicon chromosome
Accession NZ_CP087781
Organism Moraxella bovis strain SAM57978

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP129_RS05570 Protein ID WP_078275306.1
Coordinates 1060152..1060430 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP129_RS05565 Protein ID WP_078275307.1
Coordinates 1059832..1060137 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP129_RS05530 (LP129_05490) 1056353..1056685 + 333 WP_078275314.1 phage tail protein -
LP129_RS05535 (LP129_05495) 1056721..1057110 + 390 WP_078275313.1 hypothetical protein -
LP129_RS05540 (LP129_05500) 1057107..1057790 + 684 WP_264676213.1 phage minor tail protein L -
LP129_RS05545 (LP129_05505) 1057832..1058062 - 231 WP_078275311.1 Arc family DNA-binding protein -
LP129_RS05550 (LP129_05510) 1058235..1058831 + 597 WP_264676214.1 antA/AntB antirepressor family protein -
LP129_RS05555 (LP129_05515) 1058828..1059016 + 189 WP_078275309.1 hypothetical protein -
LP129_RS05560 (LP129_05520) 1059084..1059860 + 777 WP_078275308.1 C40 family peptidase -
LP129_RS05565 (LP129_05525) 1059832..1060137 - 306 WP_078275307.1 HigA family addiction module antitoxin Antitoxin
LP129_RS05570 (LP129_05530) 1060152..1060430 - 279 WP_078275306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP129_RS05575 (LP129_05535) 1060516..1061100 + 585 WP_264695705.1 tail assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1034203..1069466 35263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226132 WP_078275306.1 NZ_CP087781:c1060430-1060152 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226132 NZ_CP122315:c2825377-2825183 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226132 WP_078275307.1 NZ_CP087781:c1060137-1059832 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226132 NZ_CP122315:2825006-2825184 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References