Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 787187..787836 Replicon chromosome
Accession NZ_CP087781
Organism Moraxella bovis strain SAM57978

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP129_RS04030 Protein ID WP_078274052.1
Coordinates 787435..787836 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP129_RS04025 Protein ID WP_112741908.1
Coordinates 787187..787420 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP129_RS04005 (LP129_03980) 782583..783032 - 450 WP_264676133.1 cytochrome c -
LP129_RS04010 (LP129_03985) 783214..784206 - 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP129_RS04015 (LP129_03990) 784226..784819 - 594 WP_208624078.1 GTP cyclohydrolase II -
LP129_RS04020 (LP129_03995) 785040..787139 + 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP129_RS04025 (LP129_04000) 787187..787420 + 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP129_RS04030 (LP129_04005) 787435..787836 + 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP129_RS04035 (LP129_04010) 788360..788860 + 501 WP_112741909.1 WG repeat-containing protein -
LP129_RS04040 (LP129_04015) 788982..789812 + 831 WP_078274050.1 inositol monophosphatase family protein -
LP129_RS04045 (LP129_04020) 789911..790600 - 690 WP_078274049.1 SIMPL domain-containing protein -
LP129_RS04055 (LP129_04030) 791336..791755 - 420 WP_078274047.1 S4 domain-containing protein -
LP129_RS04060 (LP129_04035) 791752..791928 - 177 WP_228157829.1 ASCH domain-containing protein -
LP129_RS04065 (LP129_04040) 791947..792180 - 234 WP_112741910.1 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226130 WP_078274052.1 NZ_CP087781:787435-787836 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226130 NZ_CP122315:c2682458-2682351 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226130 WP_112741908.1 NZ_CP087781:787187-787420 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226130 NZ_CP122315:2682505-2682571 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References