Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 516012..516664 Replicon chromosome
Accession NZ_CP087781
Organism Moraxella bovis strain SAM57978

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP129_RS02630 Protein ID WP_078275188.1
Coordinates 516272..516664 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP129_RS02625 Protein ID WP_264675982.1
Coordinates 516012..516275 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP129_RS02595 (LP129_02575) 511297..512631 + 1335 WP_112741795.1 deoxyguanosinetriphosphate triphosphohydrolase -
LP129_RS02600 (LP129_02580) 512775..513068 + 294 WP_029103533.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP129_RS02605 (LP129_02585) 513061..513333 + 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP129_RS02610 (LP129_02590) 513398..513853 - 456 WP_264675985.1 type IV secretion protein Rhs -
LP129_RS02615 (LP129_02595) 513938..514315 + 378 WP_264675984.1 hypothetical protein -
LP129_RS02620 (LP129_02600) 514673..515932 + 1260 WP_264675983.1 replication-associated recombination protein A -
LP129_RS02625 (LP129_02605) 516012..516275 + 264 WP_264675982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP129_RS02630 (LP129_02610) 516272..516664 + 393 WP_078275188.1 type II toxin-antitoxin system VapC family toxin Toxin
LP129_RS02635 (LP129_02615) 516787..517317 + 531 WP_078275187.1 HI_0552 family protein -
LP129_RS02640 (LP129_02620) 517314..517880 - 567 WP_078275186.1 hypothetical protein -
LP129_RS02645 (LP129_02625) 517883..518119 - 237 WP_078275185.1 sulfurtransferase TusA -
LP129_RS02650 (LP129_02630) 518116..518574 - 459 WP_078275184.1 acyl-CoA thioesterase -
LP129_RS02655 (LP129_02635) 518654..519676 - 1023 WP_078275183.1 hypothetical protein -
LP129_RS02660 (LP129_02640) 519707..520585 - 879 WP_112741796.1 uroporphyrinogen-III synthase -
LP129_RS02665 (LP129_02645) 520631..521572 - 942 WP_078275181.1 hydroxymethylbilane synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14689.79 Da        Isoelectric Point: 4.7370

>T226129 WP_078275188.1 NZ_CP087781:516272-516664 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Download         Length: 393 bp

>T226129 NZ_CP122315:c2681923-2681816 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10153.49 Da        Isoelectric Point: 6.3724

>AT226129 WP_264675982.1 NZ_CP087781:516012-516275 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226129 NZ_CP122315:2681971-2682037 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References