Detailed information of TA system TA226128

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 512775..513333
• Replicon: chromosome
• Accession: NZ_CP087781
• Organism: Moraxella bovis strain SAM57978

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP129_RS02605
• Protein ID: WP_228157760.1
• Coordinates: 513061..513333 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP129_RS02600
• Protein ID: WP_029103533.1
• Coordinates: 512775..513068 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP129_RS02580 (LP129_02560)	508286..509620	-	1335	WP_078275195.1	valine--pyruvate transaminase	-
LP129_RS02585 (LP129_02565)	509740..510351	+	612	WP_112741794.1	methyltransferase	-
LP129_RS02590 (LP129_02570)	510372..511088	+	717	WP_078275193.1	hypothetical protein	-
LP129_RS02595 (LP129_02575)	511297..512631	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP129_RS02600 (LP129_02580)	512775..513068	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP129_RS02605 (LP129_02585)	513061..513333	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP129_RS02610 (LP129_02590)	513398..513853	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP129_RS02615 (LP129_02595)	513938..514315	+	378	WP_264675984.1	hypothetical protein	-
LP129_RS02620 (LP129_02600)	514673..515932	+	1260	WP_264675983.1	replication-associated recombination protein A	-
LP129_RS02625 (LP129_02605)	516012..516275	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP129_RS02630 (LP129_02610)	516272..516664	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP129_RS02635 (LP129_02615)	516787..517317	+	531	WP_078275187.1	HI_0552 family protein	-
LP129_RS02640 (LP129_02620)	517314..517880	-	567	WP_078275186.1	hypothetical protein	-
LP129_RS02645 (LP129_02625)	517883..518119	-	237	WP_078275185.1	sulfurtransferase TusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226128 WP_228157760.1 NZ_CP087781:513061-513333 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226128 NZ_CP122315:2077191-2077469 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226128 WP_029103533.1 NZ_CP087781:512775-513068 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226128 NZ_CP122315:2076928-2077188 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6