Detailed information of TA system TA226127

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 180318..180924
• Replicon: chromosome
• Accession: NZ_CP087781
• Organism: Moraxella bovis strain SAM57978

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP129_RS00925
• Protein ID: WP_228157738.1
• Coordinates: 180589..180924 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LP129_RS00920
• Protein ID: WP_078274722.1
• Coordinates: 180318..180599 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP129_RS00895 (LP129_00890)	176016..176774	+	759	WP_078274726.1	YciK family oxidoreductase	-
LP129_RS00900 (LP129_00895)	176884..178209	+	1326	WP_112741690.1	hemolysin family protein	-
LP129_RS00905 (LP129_00900)	178354..179076	+	723	WP_029103568.1	nitroreductase family protein	-
LP129_RS00910 (LP129_00905)	179116..179328	-	213	WP_078274724.1	hypothetical protein	-
LP129_RS00915 (LP129_00910)	179444..180268	-	825	WP_078274723.1	site-specific integrase	-
LP129_RS00920 (LP129_00915)	180318..180599	-	282	WP_078274722.1	NadS family protein	Antitoxin
LP129_RS00925 (LP129_00920)	180589..180924	-	336	WP_228157738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP129_RS00930 (LP129_00925)	180988..182148	-	1161	WP_078274721.1	zonular occludens toxin domain-containing protein	-
LP129_RS00935 (LP129_00930)	182234..182527	-	294	WP_078274720.1	DUF2523 family protein	-
LP129_RS00940 (LP129_00935)	182524..183399	-	876	WP_162860331.1	virulence factor TspB C-terminal domain-related protein	-
LP129_RS00945 (LP129_00940)	183892..184149	-	258	WP_112741693.1	hypothetical protein	-
LP129_RS00950 (LP129_00945)	184268..184597	+	330	WP_264676042.1	hypothetical protein	-
LP129_RS00955 (LP129_00950)	184720..184965	+	246	WP_078274709.1	hypothetical protein	-
LP129_RS00960 (LP129_00955)	185252..185527	+	276	WP_078274708.1	hypothetical protein	-
LP129_RS00965 (LP129_00960)	185522..185677	-	156	WP_158079680.1	hypothetical protein	-
LP129_RS00970	185729..185863	-	135	WP_264676041.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12636.69 Da
• Isoelectric Point: 10.0972

>T226127 WP_228157738.1 NZ_CP087781:c180924-180589 [Moraxella bovis]
MLHFAETSLFTKQIIDLMDDDEYRLLQTNLMKNPHQGDIVRGTGGVRKTRWSIDGKGKSGGSRIIYFFVDGAGIFFMLLA
YPKSKQTTLSADEKKEMLKLTTAIKEIYRAK

Nucleotide

• Length: 336 bp

>T226127 NZ_CP122315:c2071129-2070731 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10425.98 Da
• Isoelectric Point: 10.0023

>AT226127 WP_078274722.1 NZ_CP087781:c180599-180318 [Moraxella bovis]
VQNEFYDDLKASLTEALAIAKGEISPSRTFTYERPNIKDIRAKTGLSQTQFAQKLHISPKTLKNWEQGIRTPTGPAITLI
RLLDKNPDLISMA

Nucleotide

• Length: 282 bp

>AT226127 NZ_CP122315:c2071425-2071132 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA