Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2264286..2264944 Replicon chromosome
Accession NZ_CP087771
Organism Moraxella bovis strain SAM109244

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP127_RS11440 Protein ID WP_078274940.1
Coordinates 2264756..2264944 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP127_RS11435 Protein ID WP_112741846.1
Coordinates 2264286..2264693 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP127_RS11405 (LP127_11310) 2259517..2261346 - 1830 WP_078274936.1 hypothetical protein -
LP127_RS11410 (LP127_11315) 2261334..2261678 - 345 WP_078274937.1 hypothetical protein -
LP127_RS11415 (LP127_11320) 2261679..2262485 - 807 WP_112741850.1 hypothetical protein -
LP127_RS11420 (LP127_11325) 2262539..2262976 - 438 WP_162860346.1 hypothetical protein -
LP127_RS11425 (LP127_11330) 2262910..2263242 - 333 WP_112741848.1 hypothetical protein -
LP127_RS11430 (LP127_11335) 2263239..2264210 - 972 WP_112741847.1 phage tail tape measure protein -
LP127_RS11435 (LP127_11340) 2264286..2264693 - 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP127_RS11440 (LP127_11345) 2264756..2264944 - 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP127_RS11445 (LP127_11350) 2265087..2265302 - 216 WP_078274941.1 hypothetical protein -
LP127_RS11450 (LP127_11355) 2265304..2265903 - 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP127_RS11455 (LP127_11360) 2266010..2266216 - 207 WP_264676102.1 DNA-binding protein -
LP127_RS11460 (LP127_11365) 2266339..2266683 + 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP127_RS11465 (LP127_11370) 2266727..2267479 - 753 WP_078274945.1 hypothetical protein -
LP127_RS11470 (LP127_11375) 2267557..2267757 - 201 WP_264676324.1 hypothetical protein -
LP127_RS11475 (LP127_11380) 2267766..2267957 - 192 WP_264676101.1 DNA-binding protein -
LP127_RS11480 (LP127_11385) 2267972..2268181 - 210 WP_078274960.1 hypothetical protein -
LP127_RS11485 (LP127_11390) 2268346..2268645 + 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP127_RS11490 (LP127_11395) 2268840..2269127 + 288 WP_078274962.1 ORF6C domain-containing protein -
LP127_RS11495 (LP127_11400) 2269124..2269543 + 420 WP_112741841.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2255049..2269543 14494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226126 WP_078274940.1 NZ_CP087771:c2264944-2264756 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226126 NZ_CP122315:2060537-2060878 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226126 WP_112741846.1 NZ_CP087771:c2264693-2264286 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226126 NZ_CP122315:2060199-2060516 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References