Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1824528..1825126 Replicon chromosome
Accession NZ_CP087771
Organism Moraxella bovis strain SAM109244

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LP127_RS09025 Protein ID WP_078275306.1
Coordinates 1824528..1824806 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LP127_RS09030 Protein ID WP_078275307.1
Coordinates 1824821..1825126 (+) Length 102 a.a.

Genomic Context

LP127_RS09025LP127_RS09030LP127_RS09050LP127_RS09020LP127_RS09035LP127_RS09040LP127_RS09045LP127_RS09055LP127_RS09060LP127_RS09065LP127_RS09070
Location: 1824528..1824806 (279 bp)
Type: Toxin
Protein ID: WP_078275306.1
Location: 1824821..1825126 (306 bp)
Type: Antitoxin
Protein ID: WP_078275307.1
Location: 1826896..1827126 (231 bp)
Type: Others
Protein ID: WP_078275311.1
Location: 1823858..1824442 (585 bp)
Type: Others
Protein ID: WP_264676215.1
Location: 1825098..1825874 (777 bp)
Type: Others
Protein ID: WP_078275308.1
Location: 1825942..1826130 (189 bp)
Type: Others
Protein ID: WP_078275309.1
Location: 1826127..1826723 (597 bp)
Type: Others
Protein ID: WP_264676214.1
Location: 1827168..1827851 (684 bp)
Type: Others
Protein ID: WP_264676213.1
Location: 1827848..1828237 (390 bp)
Type: Others
Protein ID: WP_078275313.1
Location: 1828273..1828605 (333 bp)
Type: Others
Protein ID: WP_078275314.1
Location: 1828708..1829526 (819 bp)
Type: Others
Protein ID: WP_264722265.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LP127_RS09020 (LP127_08940)1823858..1824442-585WP_264676215.1tail assembly protein-
LP127_RS09025 (LP127_08945)1824528..1824806+279WP_078275306.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LP127_RS09030 (LP127_08950)1824821..1825126+306WP_078275307.1HigA family addiction module antitoxinAntitoxin
LP127_RS09035 (LP127_08955)1825098..1825874-777WP_078275308.1C40 family peptidase-
LP127_RS09040 (LP127_08960)1825942..1826130-189WP_078275309.1hypothetical protein-
LP127_RS09045 (LP127_08965)1826127..1826723-597WP_264676214.1antA/AntB antirepressor family protein-
LP127_RS09050 (LP127_08970)1826896..1827126+231WP_078275311.1Arc family DNA-binding protein-
LP127_RS09055 (LP127_08975)1827168..1827851-684WP_264676213.1phage minor tail protein L-
LP127_RS09060 (LP127_08980)1827848..1828237-390WP_078275313.1hypothetical protein-
LP127_RS09065 (LP127_08985)1828273..1828605-333WP_078275314.1phage tail protein-
LP127_RS09070 (LP127_08990)1828708..1829526-819WP_264722265.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1815492..185426938777


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10491.92 Da        Isoelectric Point: 5.0474

>T226123 WP_078275306.1 NZ_CP087771:1824528-1824806 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Download         Length: 279 bp

>T226123 NZ_CP122315:1428983-1429240 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11173.81 Da        Isoelectric Point: 7.3174

>AT226123 WP_078275307.1 NZ_CP087771:1824821-1825126 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Download         Length: 306 bp

>AT226123 NZ_CP122315:1429252-1429797 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References