Detailed information of TA system TA226123

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1824528..1825126
• Replicon: chromosome
• Accession: NZ_CP087771
• Organism: Moraxella bovis strain SAM109244

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LP127_RS09025
• Protein ID: WP_078275306.1
• Coordinates: 1824528..1824806 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: LP127_RS09030
• Protein ID: WP_078275307.1
• Coordinates: 1824821..1825126 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP127_RS09020 (LP127_08940)	1823858..1824442	-	585	WP_264676215.1	tail assembly protein	-
LP127_RS09025 (LP127_08945)	1824528..1824806	+	279	WP_078275306.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP127_RS09030 (LP127_08950)	1824821..1825126	+	306	WP_078275307.1	HigA family addiction module antitoxin	Antitoxin
LP127_RS09035 (LP127_08955)	1825098..1825874	-	777	WP_078275308.1	C40 family peptidase	-
LP127_RS09040 (LP127_08960)	1825942..1826130	-	189	WP_078275309.1	hypothetical protein	-
LP127_RS09045 (LP127_08965)	1826127..1826723	-	597	WP_264676214.1	antA/AntB antirepressor family protein	-
LP127_RS09050 (LP127_08970)	1826896..1827126	+	231	WP_078275311.1	Arc family DNA-binding protein	-
LP127_RS09055 (LP127_08975)	1827168..1827851	-	684	WP_264676213.1	phage minor tail protein L	-
LP127_RS09060 (LP127_08980)	1827848..1828237	-	390	WP_078275313.1	hypothetical protein	-
LP127_RS09065 (LP127_08985)	1828273..1828605	-	333	WP_078275314.1	phage tail protein	-
LP127_RS09070 (LP127_08990)	1828708..1829526	-	819	WP_264722265.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1815492..1854269	38777

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-95)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10491.92 Da
• Isoelectric Point: 5.0474

>T226123 WP_078275306.1 NZ_CP087771:1824528-1824806 [Moraxella bovis]
MIQSFKCKDAQSLFETGSSRVFANFLSVATRKLTMLDNAVALADLRIPPANRLEKLTGDREGQYSIRINDQFRICFVWGD
DGVYDVEIVDYH

Nucleotide

• Length: 279 bp

>T226123 NZ_CP122315:1428983-1429240 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11173.81 Da
• Isoelectric Point: 7.3174

>AT226123 WP_078275307.1 NZ_CP087771:1824821-1825126 [Moraxella bovis]
MFKNGMRPVHAGEVLREEYLIPMGMSATALANALGVTPARINDIVRQRRGVTADTALRLARYFGGTAQFWLNLQTTYELR
LAETTLGDSLDFISPHEVAHA

Nucleotide

• Length: 306 bp

>AT226123 NZ_CP122315:1429252-1429797 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA