Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3993108..3993727 Replicon chromosome
Accession NZ_CP087669
Organism Klebsiella pneumoniae strain KP53

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LOM31_RS19680 Protein ID WP_002892050.1
Coordinates 3993509..3993727 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LOM31_RS19675 Protein ID WP_002892066.1
Coordinates 3993108..3993482 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOM31_RS19665 (3988260) 3988260..3989453 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LOM31_RS19670 (3989476) 3989476..3992622 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LOM31_RS19675 (3993108) 3993108..3993482 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LOM31_RS19680 (3993509) 3993509..3993727 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LOM31_RS19685 (3993886) 3993886..3994452 + 567 WP_002892030.1 maltose O-acetyltransferase -
LOM31_RS19690 (3994424) 3994424..3994564 - 141 WP_004147370.1 hypothetical protein -
LOM31_RS19695 (3994585) 3994585..3995055 + 471 WP_002892026.1 YlaC family protein -
LOM31_RS19700 (3995030) 3995030..3996481 - 1452 WP_021313732.1 PLP-dependent aminotransferase family protein -
LOM31_RS19705 (3996582) 3996582..3997280 + 699 WP_002892021.1 GNAT family protein -
LOM31_RS19710 (3997277) 3997277..3997417 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LOM31_RS19715 (3997417) 3997417..3997680 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T225926 WP_002892050.1 NZ_CP087669:3993509-3993727 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T225926 NZ_CP121583:708439-708621 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT225926 WP_002892066.1 NZ_CP087669:3993108-3993482 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT225926 NZ_CP121583:708714-709118 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References