Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 111297..111550 | Replicon | plasmid pDD01653-2 |
| Accession | NZ_CP087653 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD01653 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | LL272_RS28890 | Protein ID | WP_001312851.1 |
| Coordinates | 111401..111550 (+) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 111297..111356 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LL272_RS28850 (106679) | 106679..107023 | - | 345 | Protein_148 | IS6-like element IS26 family transposase | - |
| LL272_RS28855 (107075) | 107075..107779 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| LL272_RS28860 (107804) | 107804..108004 | + | 201 | WP_072354025.1 | hypothetical protein | - |
| LL272_RS28865 (108024) | 108024..108770 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| LL272_RS28870 (108825) | 108825..109385 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| LL272_RS28875 (109517) | 109517..109717 | + | 201 | WP_015059022.1 | hypothetical protein | - |
| LL272_RS28880 (110103) | 110103..110702 | + | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| LL272_RS28885 (110764) | 110764..111096 | + | 333 | WP_152916585.1 | hypothetical protein | - |
| - (111297) | 111297..111356 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (111297) | 111297..111356 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (111297) | 111297..111356 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (111297) | 111297..111356 | - | 60 | NuclAT_1 | - | Antitoxin |
| LL272_RS28890 (111401) | 111401..111550 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| LL272_RS28895 (111834) | 111834..112082 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaCTX-M-65 / fosA3 / blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2 | - | 1..112393 | 112393 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T225856 WP_001312851.1 NZ_CP087653:111401-111550 [Klebsiella pneumoniae subsp. pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T225856 NZ_CP121480:1128539-1128727 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCCGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCCGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA
Antitoxin
Download Length: 60 bp
>AT225856 NZ_CP087653:c111356-111297 [Klebsiella pneumoniae subsp. pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
