Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1085..1670 Replicon plasmid pAb01-1
Accession NZ_CP087595
Organism Acinetobacter baumannii strain SHOU-Ab01

Toxin (Protein)


Gene name higB Uniprot ID N8ZPD7
Locus tag LOZ89_RS18645 Protein ID WP_000897309.1
Coordinates 1085..1405 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LOZ89_RS18650 Protein ID WP_000369780.1
Coordinates 1398..1670 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ89_RS18630 (LOZ89_18630) 93..308 + 216 WP_000071892.1 cold-shock protein -
LOZ89_RS18635 (LOZ89_18635) 407..634 + 228 WP_000921865.1 hypothetical protein -
LOZ89_RS18640 (LOZ89_18640) 701..898 + 198 WP_000476222.1 hypothetical protein -
LOZ89_RS18645 (LOZ89_18645) 1085..1405 + 321 WP_000897309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOZ89_RS18650 (LOZ89_18650) 1398..1670 + 273 WP_000369780.1 NadS family protein Antitoxin
LOZ89_RS18655 (LOZ89_18655) 2288..2806 + 519 WP_000447193.1 tetratricopeptide repeat protein -
LOZ89_RS18660 (LOZ89_18660) 2994..3221 - 228 WP_004812234.1 hypothetical protein -
LOZ89_RS18665 (LOZ89_18665) 3609..4133 - 525 WP_034684955.1 plasmid replication DNA-binding protein -
LOZ89_RS18670 (LOZ89_18670) 4212..5141 - 930 WP_034684953.1 replication initiation protein RepM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..8571 8571


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12209.01 Da        Isoelectric Point: 7.9835

>T225623 WP_000897309.1 NZ_CP087595:1085-1405 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T225623 NZ_CP121223:c1440879-1440772 [Shigella flexneri 2a]
ATGACGTTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10122.63 Da        Isoelectric Point: 8.6582

>AT225623 WP_000369780.1 NZ_CP087595:1398-1670 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp

>AT225623 NZ_CP121223:1440937-1440991 [Shigella flexneri 2a]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855WJQ3

Antitoxin

Source ID Structure

References