Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2013454..2015090 Replicon chromosome
Accession NZ_CP087594
Organism Acinetobacter baumannii strain SHOU-Ab01

Toxin (Protein)


Gene name hipA Uniprot ID A0A9F1U5K1
Locus tag LOZ89_RS09770 Protein ID WP_005128640.1
Coordinates 2013759..2015090 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LOZ89_RS09765 Protein ID WP_001101310.1
Coordinates 2013454..2013762 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ89_RS09740 (LOZ89_09740) 2008817..2009530 + 714 WP_005128644.1 hypothetical protein -
LOZ89_RS09745 (LOZ89_09745) 2009543..2010652 + 1110 WP_005128643.1 XRE family transcriptional regulator -
LOZ89_RS09750 (LOZ89_09750) 2010715..2011263 - 549 WP_005128641.1 TetR/AcrR family transcriptional regulator -
LOZ89_RS09755 (LOZ89_09755) 2011686..2012195 + 510 WP_230258700.1 helix-turn-helix domain-containing protein -
LOZ89_RS09760 (LOZ89_09760) 2012228..2013070 + 843 WP_223673390.1 IS3 family transposase -
LOZ89_RS09765 (LOZ89_09765) 2013454..2013762 - 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
LOZ89_RS09770 (LOZ89_09770) 2013759..2015090 - 1332 WP_005128640.1 HipA domain-containing protein Toxin
LOZ89_RS09775 (LOZ89_09775) 2015386..2015826 + 441 WP_000193136.1 HD domain-containing protein -
LOZ89_RS09780 (LOZ89_09780) 2015861..2016505 - 645 WP_005128638.1 hypothetical protein -
LOZ89_RS09785 (LOZ89_09785) 2016517..2017488 - 972 WP_086267245.1 5'/3'-nucleotidase SurE -
LOZ89_RS18780 2017615..2018793 - 1179 WP_227504097.1 TolC family protein -
LOZ89_RS18785 2018797..2019363 - 567 Protein_1917 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51189.25 Da        Isoelectric Point: 4.8549

>T225621 WP_005128640.1 NZ_CP087594:c2015090-2013759 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T225621 NZ_CP121223:c1439913-1439806 [Shigella flexneri 2a]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT225621 WP_001101310.1 NZ_CP087594:c2013762-2013454 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp

>AT225621 NZ_CP121223:1439970-1440025 [Shigella flexneri 2a]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References