Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1242111..1242762 Replicon chromosome
Accession NZ_CP087594
Organism Acinetobacter baumannii strain SHOU-Ab01

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Q0RPK1
Locus tag LOZ89_RS05910 Protein ID WP_000838147.1
Coordinates 1242111..1242293 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A335N5K1
Locus tag LOZ89_RS05915 Protein ID WP_000966690.1
Coordinates 1242358..1242762 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOZ89_RS05880 (LOZ89_05880) 1238498..1239601 + 1104 WP_033855665.1 minor capsid protein -
LOZ89_RS05885 (LOZ89_05885) 1239646..1240038 + 393 WP_001992845.1 hypothetical protein -
LOZ89_RS05890 (LOZ89_05890) 1240137..1240373 + 237 WP_000004365.1 hypothetical protein -
LOZ89_RS05895 (LOZ89_05895) 1240596..1240787 + 192 WP_001139861.1 hypothetical protein -
LOZ89_RS05900 (LOZ89_05900) 1240900..1241667 + 768 WP_230258729.1 hypothetical protein -
LOZ89_RS05905 (LOZ89_05905) 1241695..1241802 + 108 Protein_1139 major capsid protein -
LOZ89_RS05910 (LOZ89_05910) 1242111..1242293 + 183 WP_000838147.1 type II toxin-antitoxin system HicA family toxin Toxin
LOZ89_RS05915 (LOZ89_05915) 1242358..1242762 + 405 WP_000966690.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOZ89_RS05920 (LOZ89_05920) 1242861..1243037 + 177 WP_001983384.1 hypothetical protein -
LOZ89_RS05925 (LOZ89_05925) 1243046..1243369 + 324 WP_000523922.1 DUF4236 domain-containing protein -
LOZ89_RS05930 (LOZ89_05930) 1243403..1243936 + 534 WP_000719143.1 hypothetical protein -
LOZ89_RS05935 (LOZ89_05935) 1243948..1244349 + 402 WP_000758222.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1215429..1268886 53457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6682.88 Da        Isoelectric Point: 10.6602

>T225620 WP_000838147.1 NZ_CP087594:1242111-1242293 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK

Download         Length: 183 bp

>T225620 NZ_CP121223:c1362657-1362382 [Shigella flexneri 2a]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
TGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14605.61 Da        Isoelectric Point: 4.4169

>AT225620 WP_000966690.1 NZ_CP087594:1242358-1242762 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT225620 NZ_CP121223:c1362385-1362026 [Shigella flexneri 2a]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGAG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q0RPK1

Antitoxin

Source ID Structure
AlphaFold DB A0A335N5K1

References