225619

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2597014..2597537 Replicon chromosome
Accession NZ_CP087593
Organism Staphylococcus aureus strain Newman NM-CQ

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag LO764_RS13270 Protein ID WP_000074048.1
Coordinates 2597014..2597280 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag LO764_RS13275 Protein ID WP_000587616.1
Coordinates 2597280..2597537 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO764_RS13250 (2592321) 2592321..2593508 - 1188 WP_000026194.1 MFS transporter -
LO764_RS13255 (2593904) 2593904..2594680 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
LO764_RS13260 (2594673) 2594673..2595335 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
LO764_RS13265 (2595583) 2595583..2596659 - 1077 WP_001076671.1 M42 family metallopeptidase -
LO764_RS13270 (2597014) 2597014..2597280 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
LO764_RS13275 (2597280) 2597280..2597537 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LO764_RS13280 (2597896) 2597896..2598351 + 456 WP_000732082.1 DUF1307 domain-containing protein -
LO764_RS13285 (2598519) 2598519..2600096 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
LO764_RS13290 (2600291) 2600291..2601040 + 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
LO764_RS13295 (2601264) 2601264..2602457 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T225619 WP_000074048.1 NZ_CP087593:c2597280-2597014 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T225619 NZ_CP121223:c996884-996570 [Shigella flexneri 2a]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT225619 WP_000587616.1 NZ_CP087593:c2597537-2597280 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT225619 NZ_CP121223:c996573-996157 [Shigella flexneri 2a]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References