Detailed information of TA system TA225617

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2565514..2565698
• Replicon: chromosome
• Accession: NZ_CP087593
• Organism: Staphylococcus aureus strain Newman NM-CQ

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: LO764_RS13130
• Protein ID: WP_000482650.1
• Coordinates: 2565591..2565698 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2565514..2565574 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO764_RS13115	2561044..2561211	-	168	WP_001790576.1	hypothetical protein	-
LO764_RS13120	2561442..2563175	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
LO764_RS13125	2563200..2564963	-	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
-	2565514..2565574	+	61	-	-	Antitoxin
LO764_RS13130	2565591..2565698	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
LO764_RS13135	2565832..2566218	-	387	WP_000779358.1	flippase GtxA	-
LO764_RS13140	2566486..2567628	+	1143	WP_001176863.1	glycerate kinase	-
LO764_RS13145	2567688..2568347	+	660	WP_000831298.1	membrane protein	-
LO764_RS13150	2568529..2569740	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
LO764_RS13155	2569863..2570336	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T225617 WP_000482650.1 NZ_CP087593:c2565698-2565591 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T225617 NZ_CP121223:c749074-748667 [Shigella flexneri 2a]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT225617 NZ_CP087593:2565514-2565574 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin