Detailed information of TA system TA022535

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 6472881..6473461
• Replicon: chromosome
• Accession: NC_010002
• Organism: Delftia acidovorans SPH-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A9C0Y2
• Locus tag: DACI_RS29405
• Protein ID: WP_012207614.1
• Coordinates: 6473081..6473461 (+)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A9C0Y1
• Locus tag: DACI_RS29400
• Protein ID: WP_012207613.1
• Coordinates: 6472881..6473084 (+)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DACI_RS29390	6470112..6471788	-	1677	WP_012207611.1	VRR-NUC domain-containing protein	-
DACI_RS29395	6471898..6472710	-	813	WP_012207612.1	glucose 1-dehydrogenase	-
DACI_RS29400	6472881..6473084	+	204	WP_012207613.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
DACI_RS29405	6473081..6473461	+	381	WP_012207614.1	type II toxin-antitoxin system VapC family toxin	Toxin
DACI_RS29410	6473511..6475388	-	1878	WP_012207615.1	CocE/NonD family hydrolase	-
DACI_RS29415	6475400..6476377	-	978	WP_043782962.1	tripartite tricarboxylate transporter substrate binding protein	-
DACI_RS29420	6476414..6477430	-	1017	WP_012207617.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-114)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-43)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13931.34 Da
• Isoelectric Point: 8.5635

>T22535 WP_012207614.1 NC_010002:6473081-6473461 [Delftia acidovorans SPH-1]
MNPVLVDTSVWIDHFRQGNPHLVQLLQQDMTLMHPLVLGELACGTPPARARTLADLQRLKPARQASMREVMALIEREQLF
GLGCGLVDMTLLASALMSSGASLWSLDKRLHALAQRFGIAYRPTGQ

Nucleotide

• Length: 381 bp

>T22535 NC_010002:6473081-6473461 [Delftia acidovorans SPH-1]
ATGAATCCCGTTCTGGTCGATACCTCGGTCTGGATCGATCACTTCAGGCAGGGCAATCCTCACCTGGTGCAGCTGCTGCA
GCAAGACATGACGCTCATGCACCCCCTGGTGCTGGGCGAACTGGCCTGCGGCACGCCACCGGCACGCGCACGCACGCTCG
CAGACCTTCAACGGCTCAAGCCTGCCCGGCAGGCCAGCATGCGCGAAGTGATGGCCTTGATAGAGCGCGAGCAGCTCTTT
GGTCTGGGCTGCGGCCTGGTGGACATGACGCTCCTGGCCTCGGCACTCATGTCTTCAGGCGCCAGCCTGTGGTCGCTGGA
CAAGCGCCTGCACGCGCTGGCCCAGCGGTTTGGCATTGCCTACCGTCCCACAGGCCAGTAG

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7485.58 Da
• Isoelectric Point: 4.5702

>AT22535 WP_012207613.1 NC_010002:6472881-6473084 [Delftia acidovorans SPH-1]
MRTTVTIDDALYEEALELAEPEMDKADLFREAVKTFVRVQAAKRLAALGGSAPDMREIPRRPQGIEP

Nucleotide

• Length: 204 bp

>AT22535 NC_010002:6472881-6473084 [Delftia acidovorans SPH-1]
ATGAGAACCACGGTCACCATCGACGACGCCTTGTACGAGGAAGCGCTGGAGCTGGCGGAGCCAGAAATGGACAAGGCCGA
CCTGTTTCGCGAAGCCGTCAAGACTTTCGTGAGAGTGCAGGCGGCCAAGCGCCTGGCCGCGCTGGGAGGCAGCGCACCGG
ACATGCGGGAGATTCCCCGTCGCCCACAGGGCATCGAGCCATGA

Structures

Toxin

• AlphaFold DB: A9C0Y2

Antitoxin

• AlphaFold DB: A9C0Y1