Detailed information of TA system TA022533

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1876687..1877276
• Replicon: chromosome
• Accession: NC_010002
• Organism: Delftia acidovorans SPH-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A9BSX0
• Locus tag: DACI_RS08485
• Protein ID: WP_012203615.1
• Coordinates: 1876980..1877276 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A9BSW9
• Locus tag: DACI_RS08480
• Protein ID: WP_012203614.1
• Coordinates: 1876687..1876983 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DACI_RS08465	1872551..1873165	+	615	WP_012203611.1	SCO family protein	-
DACI_RS08470	1873327..1874904	+	1578	WP_012203612.1	PAS domain-containing methyl-accepting chemotaxis protein	-
DACI_RS08475	1874901..1876658	+	1758	WP_012203613.1	GGDEF domain-containing phosphodiesterase	-
DACI_RS08480	1876687..1876983	-	297	WP_012203614.1	putative addiction module antidote protein	Antitoxin
DACI_RS08485	1876980..1877276	-	297	WP_012203615.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DACI_RS08490	1877324..1878007	-	684	WP_043780967.1	Crp/Fnr family transcriptional regulator	-
DACI_RS08495	1878243..1879220	-	978	WP_012203617.1	hypothetical protein	-
DACI_RS08500	1879220..1881172	-	1953	WP_012203618.1	StlD/DarB family beta-ketosynthase	-
DACI_RS08505	1881188..1882123	-	936	WP_012203619.1	fatty acid desaturase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-89)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11232.01 Da
• Isoelectric Point: 10.0308

>T22533 WP_012203615.1 NC_010002:c1877276-1876980 [Delftia acidovorans SPH-1]
MYSVIETEAFADWVDSIRDIPTRIRLRRRLGKAMRGNLGDVKSVGEGLWEMREFFGPGWRMYYIQRDHVLIVMLGGGDKS
SQAQDIAAARAMAREIKL

Nucleotide

• Length: 297 bp

>T22533 NC_010002:c1877276-1876980 [Delftia acidovorans SPH-1]
ATGTACAGCGTCATCGAAACCGAGGCGTTTGCTGATTGGGTAGACAGCATTCGTGACATACCAACTCGTATCCGCCTGCG
TCGTCGCCTGGGCAAAGCCATGCGCGGAAACCTGGGAGACGTGAAATCCGTTGGCGAGGGCCTATGGGAGATGCGCGAGT
TTTTTGGGCCAGGTTGGCGCATGTACTACATCCAACGCGATCATGTTCTGATCGTGATGCTTGGCGGCGGAGACAAGTCC
AGCCAGGCACAGGACATTGCTGCGGCCAGGGCGATGGCCAGGGAGATCAAGCTATGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10768.22 Da
• Isoelectric Point: 4.6151

>AT22533 WP_012203614.1 NC_010002:c1876983-1876687 [Delftia acidovorans SPH-1]
MSNIKMRPFDMANYLGTEEEIVEYLRQALEDNDPAELAAALGDIARARGMTQLARDTGLSRESLYKSLSGERAPSSETLF
KVIQAMGFRLTIAPAASQ

Nucleotide

• Length: 297 bp

>AT22533 NC_010002:c1876983-1876687 [Delftia acidovorans SPH-1]
ATGAGCAACATCAAGATGCGGCCATTCGACATGGCCAACTACCTCGGCACCGAAGAGGAAATCGTGGAGTACCTGCGCCA
GGCGCTGGAAGACAACGATCCGGCCGAACTGGCTGCGGCGCTGGGCGACATCGCACGCGCGCGCGGCATGACTCAGCTCG
CTCGCGACACCGGACTTTCTCGGGAAAGCCTCTACAAAAGCCTGTCTGGCGAACGGGCGCCCAGTTCCGAGACGCTGTTC
AAGGTGATTCAGGCCATGGGCTTCAGGCTCACCATCGCTCCTGCCGCATCGCAGTAG

Structures

Toxin

• AlphaFold DB: A9BSX0

Antitoxin

• AlphaFold DB: A9BSW9