Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3407204..3408002 Replicon chromosome
Accession NZ_CP087290
Organism Escherichia coli strain APEC 102026

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag LO741_RS16470 Protein ID WP_000854730.1
Coordinates 3407204..3407581 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag LO741_RS16475 Protein ID WP_001285481.1
Coordinates 3407628..3408002 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO741_RS16440 (3403002) 3403002..3403196 - 195 WP_001313570.1 DUF957 domain-containing protein -
LO741_RS16445 (3403238) 3403238..3403529 + 292 Protein_3201 transposase -
LO741_RS16450 (3403526) 3403526..3403876 + 351 WP_000624707.1 IS66 family insertion sequence element accessory protein TnpB -
LO741_RS16455 (3403907) 3403907..3405500 + 1594 Protein_3203 IS66 family transposase -
LO741_RS16460 (3405648) 3405648..3406636 + 989 Protein_3204 IS630 family transposase -
LO741_RS16465 (3406715) 3406715..3407207 - 493 Protein_3205 DUF5983 family protein -
LO741_RS16470 (3407204) 3407204..3407581 - 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
LO741_RS16475 (3407628) 3407628..3408002 - 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LO741_RS16480 (3408052) 3408052..3408696 - 645 WP_000086759.1 hypothetical protein -
LO741_RS16485 (3408715) 3408715..3408936 - 222 WP_000692315.1 DUF987 domain-containing protein -
LO741_RS16490 (3408999) 3408999..3409475 - 477 WP_001313574.1 RadC family protein -
LO741_RS16495 (3409491) 3409491..3409964 - 474 WP_139508664.1 antirestriction protein -
LO741_RS16500 (3410058) 3410058..3410303 - 246 WP_001164966.1 hypothetical protein -
LO741_RS16505 (3410303) 3410303..3411124 - 822 WP_001234359.1 DUF932 domain-containing protein -
LO741_RS16510 (3411224) 3411224..3411457 - 234 WP_001213776.1 DUF905 family protein -
LO741_RS16515 (3411575) 3411575..3412027 - 453 WP_000682723.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T225269 WP_000854730.1 NZ_CP087290:c3407581-3407204 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T225269 NZ_CP121088:145613-146029 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT225269 WP_001285481.1 NZ_CP087290:c3408002-3407628 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT225269 NZ_CP121088:145386-145616 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References