Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1385424..1386222 Replicon chromosome
Accession NZ_CP087290
Organism Escherichia coli strain APEC 102026

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag LO741_RS06630 Protein ID WP_000854735.1
Coordinates 1385845..1386222 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag LO741_RS06625 Protein ID WP_032153712.1
Coordinates 1385424..1385798 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO741_RS06590 (1381157) 1381157..1382041 + 885 WP_024166630.1 50S ribosome-binding GTPase -
LO741_RS06595 (1382160) 1382160..1382837 + 678 WP_023155728.1 hypothetical protein -
LO741_RS06600 (1382867) 1382867..1383076 + 210 WP_023155727.1 DUF905 family protein -
LO741_RS06605 (1383167) 1383167..1383985 + 819 WP_001234693.1 DUF932 domain-containing protein -
LO741_RS06610 (1384077) 1384077..1384562 + 486 WP_032153711.1 antirestriction protein -
LO741_RS06615 (1384578) 1384578..1385054 + 477 WP_001186715.1 RadC family protein -
LO741_RS06620 (1385123) 1385123..1385344 + 222 WP_000692345.1 DUF987 domain-containing protein -
LO741_RS06625 (1385424) 1385424..1385798 + 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
LO741_RS06630 (1385845) 1385845..1386222 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
LO741_RS06635 (1386219) 1386219..1386710 + 492 WP_023155722.1 DUF5983 family protein -
LO741_RS06640 (1386722) 1386722..1386919 + 198 WP_000839265.1 DUF957 domain-containing protein -
LO741_RS06645 (1387004) 1387004..1387870 + 867 WP_032153714.1 DUF4942 domain-containing protein -
LO741_RS06650 (1387942) 1387942..1388205 + 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
LO741_RS06655 (1388202) 1388202..1388528 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
LO741_RS06660 (1388992) 1388992..1390254 + 1263 WP_001218753.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gspM / gspL / gspK / gspJ / gspI / gspH 1342030..1460127 118097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T225254 WP_000854735.1 NZ_CP087290:1385845-1386222 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T225254 NZ_CP121087:2418845-2419186 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT225254 WP_032153712.1 NZ_CP087290:1385424-1385798 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT225254 NZ_CP121087:c2418850-2418774 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References