Detailed information of TA system TA022524

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ygfYX/Cpta(toxin)
• Location: 1508916..1509585
• Replicon: chromosome
• Accession: NC_009997
• Organism: Shewanella baltica OS195

Toxin (Protein)

• Gene name: ygfX
• Uniprot ID: A9L5M8
• Locus tag: SBAL195_RS06510
• Protein ID: WP_012088602.1
• Coordinates: 1509145..1509585 (+)
• Length: 147 a.a.

Antitoxin (Protein)

• Gene name: ygfY
• Uniprot ID: -
• Locus tag: SBAL195_RS06505
• Protein ID: WP_006080770.1
• Coordinates: 1508916..1509164 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL195_RS06480	1504573..1505382	+	810	WP_006085061.1	prolipoprotein diacylglyceryl transferase	-
SBAL195_RS06485	1505379..1506173	+	795	WP_006085062.1	thymidylate synthase	-
SBAL195_RS06490	1506291..1507460	+	1170	WP_006085063.1	Na+/H+ antiporter NhaA	-
SBAL195_RS06495	1507463..1507849	+	387	WP_006080768.1	hypothetical protein	-
SBAL195_RS06500	1507922..1508830	+	909	WP_006085064.1	transcriptional activator NhaR	-
SBAL195_RS06505	1508916..1509164	+	249	WP_006080770.1	succinate dehydrogenase assembly factor 2	Antitoxin
SBAL195_RS06510	1509145..1509585	+	441	WP_012088602.1	hypothetical protein	Toxin
SBAL195_RS06515	1509645..1511258	-	1614	WP_012196790.1	L-aspartate oxidase	-
SBAL195_RS06520	1511448..1512026	+	579	WP_006080773.1	RNA polymerase sigma factor RpoE	-
SBAL195_RS06525	1512068..1512694	+	627	WP_006080774.1	anti-sigma factor	-
SBAL195_RS06530	1512707..1513639	+	933	WP_006080775.1	MucB/RseB C-terminal domain-containing protein	-
SBAL195_RS06535	1513650..1514123	+	474	WP_006080776.1	SoxR reducing system RseC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (6-135)

Antitoxin

• Flavinator of succinate dehydrogenase (7-77)

Sequences

Toxin

Protein

• Length: 147 a.a.
• Molecular weight: 17252.42 Da
• Isoelectric Point: 8.3668

>T22524 WP_012088602.1 NC_009997:1509145-1509585 [Shewanella baltica OS195]
VEDRHHSFSVKASFDQRLSLVVFICVCASSFLLWPQSDNLALSLLKYLFILLVCIFLLSQLWRLQHWRLDFVLSDKGVGR
LSTGEHFQVLKRTWVTPFVCLMYIEVDTQLRLLMVWADMLDDTDYRHLCRLLLRAKIKQTKPHTEI

Nucleotide

• Length: 441 bp

>T22524 NC_009997:1509145-1509585 [Shewanella baltica OS195]
GTGGAAGACCGGCACCATAGTTTCAGCGTAAAAGCCTCCTTCGACCAACGACTCTCGTTGGTCGTTTTTATTTGTGTCTG
TGCTAGCTCATTTCTGCTCTGGCCTCAAAGCGACAATCTCGCCTTATCCCTGCTTAAATATCTGTTTATCCTGCTAGTTT
GTATTTTCTTGCTATCACAGTTGTGGCGACTGCAGCATTGGCGTTTAGATTTTGTGCTTAGTGATAAAGGCGTGGGACGT
TTGTCAACGGGTGAGCACTTTCAGGTATTAAAGCGAACTTGGGTGACGCCCTTTGTTTGCTTGATGTACATCGAAGTGGA
TACTCAGTTACGGCTCTTGATGGTTTGGGCGGATATGTTAGACGATACTGACTATCGGCATTTATGTCGGCTGTTGCTGC
GGGCTAAAATAAAACAGACTAAACCTCATACCGAGATTTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9723.36 Da
• Isoelectric Point: 4.4929

>AT22524 WP_006080770.1 NC_009997:1508916-1509164 [Shewanella baltica OS195]
MELMNIARVRWACRRGMLELDVLFQPFVENFYQEMSDEDKTVFIRLLECEDPELFAWFMGHEVCPDAELARMVVKVRGRP
AP

Nucleotide

• Length: 249 bp

>AT22524 NC_009997:1508916-1509164 [Shewanella baltica OS195]
TTGGAATTAATGAACATCGCAAGGGTTCGCTGGGCATGTCGCCGCGGGATGCTAGAATTAGACGTTTTGTTTCAACCTTT
TGTTGAAAATTTCTATCAAGAAATGTCCGATGAAGATAAAACTGTGTTTATCCGTTTGTTGGAATGTGAAGATCCCGAAT
TGTTTGCATGGTTTATGGGCCATGAAGTGTGCCCTGATGCTGAGCTCGCGCGTATGGTAGTGAAAGTCCGTGGAAGACCG
GCACCATAG

Structures

Toxin

• AlphaFold DB: A9L5M8