Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1748357..1748952 Replicon chromosome
Accession NZ_CP087204
Organism Pseudomonas sp. B21-054

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LOY70_RS07785 Protein ID WP_265037988.1
Coordinates 1748357..1748665 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LOY70_RS07790 Protein ID WP_265035224.1
Coordinates 1748665..1748952 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY70_RS07750 (LOY70_07730) 1744676..1745086 + 411 WP_265035212.1 hypothetical protein -
LOY70_RS07755 (LOY70_07735) 1745215..1745382 + 168 Protein_1531 transposase -
LOY70_RS07760 (LOY70_07740) 1745422..1746087 + 666 WP_265035214.1 deaminase domain-containing protein -
LOY70_RS07765 (LOY70_07745) 1746087..1746440 + 354 WP_265035216.1 Imm2 family immunity protein -
LOY70_RS07770 (LOY70_07750) 1746645..1747073 + 429 WP_092446287.1 Sbal_3080 family lipoprotein -
LOY70_RS07775 (LOY70_07755) 1747070..1747501 + 432 WP_265035220.1 DUF2846 domain-containing protein -
LOY70_RS07780 (LOY70_07760) 1747548..1747808 - 261 WP_265035222.1 hypothetical protein -
LOY70_RS07785 (LOY70_07765) 1748357..1748665 + 309 WP_265037988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY70_RS07790 (LOY70_07770) 1748665..1748952 + 288 WP_265035224.1 HigA family addiction module antitoxin Antitoxin
LOY70_RS07795 (LOY70_07775) 1748963..1749121 - 159 Protein_1539 putative addiction module antidote protein -
LOY70_RS07800 (LOY70_07780) 1749174..1749446 - 273 WP_265035226.1 hypothetical protein -
LOY70_RS07805 (LOY70_07785) 1749709..1750440 - 732 WP_265035228.1 thioredoxin family protein -
LOY70_RS07810 (LOY70_07790) 1750628..1751020 + 393 WP_123414695.1 transcriptional regulator -
LOY70_RS07815 (LOY70_07795) 1751161..1752027 - 867 WP_265035231.1 DUF6279 family lipoprotein -
LOY70_RS07820 (LOY70_07800) 1752136..1752852 - 717 WP_265035232.1 TorF family putative porin -
LOY70_RS07825 (LOY70_07805) 1753048..1753236 - 189 WP_025212437.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(54-102)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-83)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 12115.72 Da        Isoelectric Point: 4.3299

>T225136 WP_265037988.1 NZ_CP087204:1748357-1748665 [Pseudomonas sp. B21-054]
IPKPMKTDWERLLRMDDEGIDTTDIPELDEDFFRCAELLVPVEQAVTLDLEKINNKDIPDFRLHPLKGAMRGRWSIMVNG
NWRLTFEFRDGNAYVLDYEDYH

Download         Length: 309 bp

>T225136 NZ_CP121003:c989029-988502 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10623.21 Da        Isoelectric Point: 6.2168

>AT225136 WP_265035224.1 NZ_CP087204:1748665-1748952 [Pseudomonas sp. B21-054]
MNLHNPPHPGEFITEIYLEPNTISGRELAEKLGVVPSTLSRVLKGTSRVSPEMALRLSVALGRSPESWLAMQDAYDLWIA
RQHVDLQQVEKLAFA

Download         Length: 288 bp

>AT225136 NZ_CP121003:c989316-989026 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References