Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 3751950..3752571 | Replicon | chromosome |
| Accession | NZ_CP087199 | ||
| Organism | Pseudomonas sp. B21-009 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LOY34_RS17125 | Protein ID | WP_258663684.1 |
| Coordinates | 3751950..3752132 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LOY34_RS17130 | Protein ID | WP_258663685.1 |
| Coordinates | 3752170..3752571 (+) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOY34_RS17085 (LOY34_17065) | 3747365..3748666 | - | 1302 | WP_258663674.1 | terminase large subunit | - |
| LOY34_RS17090 (LOY34_17070) | 3748653..3749114 | - | 462 | WP_258663676.1 | DUF2280 domain-containing protein | - |
| LOY34_RS17095 (LOY34_17075) | 3749146..3749769 | - | 624 | WP_258663678.1 | putative metallopeptidase | - |
| LOY34_RS17100 (LOY34_17080) | 3749744..3750196 | - | 453 | WP_258663680.1 | proteasome subunit beta | - |
| LOY34_RS17105 (LOY34_17085) | 3750205..3750435 | - | 231 | WP_258663681.1 | hypothetical protein | - |
| LOY34_RS17110 (LOY34_17090) | 3750496..3750759 | - | 264 | WP_258593561.1 | hypothetical protein | - |
| LOY34_RS17115 (LOY34_17095) | 3750761..3751084 | - | 324 | WP_258593563.1 | peptidase M48, Ste24p | - |
| LOY34_RS17120 (LOY34_17100) | 3751141..3751818 | - | 678 | WP_045194466.1 | hypothetical protein | - |
| LOY34_RS17125 (LOY34_17105) | 3751950..3752132 | + | 183 | WP_258663684.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LOY34_RS17130 (LOY34_17110) | 3752170..3752571 | + | 402 | WP_258663685.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LOY34_RS17135 (LOY34_17115) | 3752686..3753276 | - | 591 | WP_258663687.1 | hypothetical protein | - |
| LOY34_RS17140 (LOY34_17120) | 3753578..3754180 | - | 603 | WP_258663689.1 | recombination protein NinG | - |
| LOY34_RS17145 (LOY34_17125) | 3754177..3754647 | - | 471 | WP_258663691.1 | hypothetical protein | - |
| LOY34_RS17150 (LOY34_17130) | 3754640..3755176 | - | 537 | WP_258663693.1 | hypothetical protein | - |
| LOY34_RS17155 (LOY34_17135) | 3755328..3756089 | - | 762 | WP_258663694.1 | replication protein P | - |
| LOY34_RS17160 (LOY34_17140) | 3756086..3756868 | - | 783 | WP_258663697.1 | DnaT-like ssDNA-binding domain-containing protein | - |
| LOY34_RS17165 (LOY34_17145) | 3756865..3757542 | - | 678 | WP_258663699.1 | phage antirepressor KilAC domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3724940..3794868 | 69928 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6724.87 Da Isoelectric Point: 11.4350
>T225114 WP_258663684.1 NZ_CP087199:3751950-3752132 [Pseudomonas sp. B21-009]
VQSRQLIKELEAAGWVLKRVTGSHHIFRHPNNPNSIPVPHPKKDLPIGTVKSIKERAGLK
VQSRQLIKELEAAGWVLKRVTGSHHIFRHPNNPNSIPVPHPKKDLPIGTVKSIKERAGLK
Download Length: 183 bp
>T225114 NZ_CP120974:2670985-2671236 [Moellerella wisconsensis]
ATGAAAGCGGTAAGCTACAGTGAAGCCAGACAGAATTTATCAACAACAATGATTCAAACAGTTGAAGATAGAGTACCAGT
ACTGATCACGCGCCAGAATGGCGAATCATGTGTACTGATGTCTCTCGATGAATATAACTCTCTCGAAGAGACGGCATACC
TAATGAGATCACCAAAAAATGCACGCAGACTTATGGACTCGATAGAAAGCCTAAAAGATGGAAAAGGGATGGAAAGGGAA
ATTATTAAGTGA
ATGAAAGCGGTAAGCTACAGTGAAGCCAGACAGAATTTATCAACAACAATGATTCAAACAGTTGAAGATAGAGTACCAGT
ACTGATCACGCGCCAGAATGGCGAATCATGTGTACTGATGTCTCTCGATGAATATAACTCTCTCGAAGAGACGGCATACC
TAATGAGATCACCAAAAAATGCACGCAGACTTATGGACTCGATAGAAAGCCTAAAAGATGGAAAAGGGATGGAAAGGGAA
ATTATTAAGTGA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14554.51 Da Isoelectric Point: 4.3588
>AT225114 WP_258663685.1 NZ_CP087199:3752170-3752571 [Pseudomonas sp. B21-009]
MQYPICIEWGDENTAIGIQVPDIPGAVTAGDTFEEAYTAAVEVAHIMLEEIASNGQAIPMPTTAATHRSNPDFADMGWGM
IEIDITPYLGKTEKVNVTLPGFVIQRIDRYVRDHNVKSRSSFLADAAMEKLGK
MQYPICIEWGDENTAIGIQVPDIPGAVTAGDTFEEAYTAAVEVAHIMLEEIASNGQAIPMPTTAATHRSNPDFADMGWGM
IEIDITPYLGKTEKVNVTLPGFVIQRIDRYVRDHNVKSRSSFLADAAMEKLGK
Download Length: 402 bp
>AT225114 NZ_CP120974:2671233-2671487 [Moellerella wisconsensis]
GTGAAGCTAACATGGTCTGCCGAAGCATGGGAAGATTACTTGTACTGGCAAGAAACGGACAGAAAAACCGTAAAAAAGAT
AAATGAGCTCATTAAGAATGCCAGTAGAACACCATTTGAAGGAAAAGGTAAACCTGAACCTCTGAAACACAATCTTGCTG
GGTTCTGGTCACGAAGAATTACGGCGGAACATCGATTAGTCTATGCCGTTAGTAATGATTCCTTGCTAATAGCATCATGT
CGTTATCACTACTGA
GTGAAGCTAACATGGTCTGCCGAAGCATGGGAAGATTACTTGTACTGGCAAGAAACGGACAGAAAAACCGTAAAAAAGAT
AAATGAGCTCATTAAGAATGCCAGTAGAACACCATTTGAAGGAAAAGGTAAACCTGAACCTCTGAAACACAATCTTGCTG
GGTTCTGGTCACGAAGAATTACGGCGGAACATCGATTAGTCTATGCCGTTAGTAATGATTCCTTGCTAATAGCATCATGT
CGTTATCACTACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|