Detailed information of TA system TA225102

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 2400264..2400918
• Replicon: chromosome
• Accession: NZ_CP087196
• Organism: Pseudomonas sp. B21-015

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LOY38_RS10930
• Protein ID: WP_223490197.1
• Coordinates: 2400568..2400918 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LOY38_RS10925
• Protein ID: WP_223489915.1
• Coordinates: 2400264..2400578 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY38_RS10895 (LOY38_10890)	2396027..2396227	+	201	WP_258700023.1	co-regulatory protein PtrA N-terminal domain-containing protein	-
LOY38_RS10900 (LOY38_10895)	2396307..2396639	+	333	WP_258700024.1	DUF2790 domain-containing protein	-
LOY38_RS10905 (LOY38_10900)	2397118..2397498	+	381	WP_258700025.1	DUF6124 family protein	-
LOY38_RS10910 (LOY38_10905)	2397794..2398087	+	294	WP_223489909.1	DUF1778 domain-containing protein	-
LOY38_RS10915 (LOY38_10910)	2398045..2398566	+	522	WP_223489911.1	hypothetical protein	-
LOY38_RS10920 (LOY38_10915)	2398762..2400087	-	1326	WP_258700026.1	OprD family porin	-
LOY38_RS10925 (LOY38_10920)	2400264..2400578	-	315	WP_223489915.1	transcriptional regulator	Antitoxin
LOY38_RS10930 (LOY38_10925)	2400568..2400918	-	351	WP_223490197.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOY38_RS10935 (LOY38_10930)	2401293..2401757	+	465	WP_258700027.1	GNAT family N-acetyltransferase	-
LOY38_RS10940 (LOY38_10935)	2402076..2402324	-	249	WP_258700028.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
LOY38_RS10945 (LOY38_10940)	2402533..2403996	-	1464	WP_007905081.1	NADH-quinone oxidoreductase subunit NuoN	-
LOY38_RS10950 (LOY38_10945)	2404004..2405536	-	1533	WP_046037834.1	NADH-quinone oxidoreductase subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (41-100)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 14017.76 Da
• Isoelectric Point: 6.4801

>T225102 WP_223490197.1 NZ_CP087196:c2400918-2400568 [Pseudomonas sp. B21-015]
MDALFIELPAFQKHRDDYLDDDLFRSFQLELLKNPEAGDLIEGTGGLRKIRFFDQRRGKGKRSGLRVIYYWWSGFDQFWL
FTVYSKNEQEDLSPDQKKLFRQTLDREINTRTHYET

Nucleotide

• Length: 351 bp

>T225102 NZ_CP120969:c3941781-3941377 [Pseudomonas putida]
ATGCTGAAGTACATGCTTGATACCAACATGTGCATTTTCACGATCAAGAATCGCCCTGAGCAGGTGCGGGAAGCCTTCAA
GCGCCATTCAGGGCAGCTGAGCATTAGCACTGTCACCCTGATGGAGCTTATTTACGGCGCCGAGAAGTCCGCTAATCCCG
AGCGTAATCTGGCGGACGTTGAAGGTTTCGCTGCGCGCTTGGAAGTACTGCCTTACGACGCTCAGGCAGCGGCTCATTCC
GGGCAATTGCGAGCTGAGTTGGCTCGTATCGGCAAGCCTATTGGCCCGTATGATCAGATGATTGCAGGACACGCACGTGC
CCAGGGACTGATTCTGGTCACGAATAATCTTCGTGAGTTCGAGCGAGTCCCAGGTTTGCGCGTCGAGGATTGGGTGAACG
CCTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11905.76 Da
• Isoelectric Point: 8.6820

>AT225102 WP_223489915.1 NZ_CP087196:c2400578-2400264 [Pseudomonas sp. B21-015]
MKRDIFSELMEGLEALADERQGKVTLRTHKVKLPELVPITAEEVVAIRQQLNLSRSVFAMYLRTNTRTLENWEQGRATPN
AQATTLIRLVERFPQTIEQLAALT

Nucleotide

• Length: 315 bp

>AT225102 NZ_CP120969:c3942011-3941781 [Pseudomonas putida]
ATGGAACAAGGTGCAGTTTTTCAGAGCAACCGCAGTCAGGCGGTGCGTTTGCCCAAGGCGGTTGCGCTGCCTGAGGATGT
GAAACGGGTGGATGTAGTAGTAGTTGGTCGAGCCCGAATCATCACGCCGGCAGGCGAGGCCTGGGACGTCTGGTTCGATG
GCGAAGGTGTGACCGCTGACTACATGGCGGATCGCGAGCAGCCTGCAGATCAAGAGCGGGATGCGTTCTGA