Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5211938..5212587 Replicon chromosome
Accession NZ_CP087185
Organism Pseudomonas sichuanensis strain B21-027

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOY51_RS23490 Protein ID WP_125465620.1
Coordinates 5212405..5212587 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOY51_RS23485 Protein ID WP_125465619.1
Coordinates 5211938..5212348 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY51_RS23460 (LOY51_23420) 5207935..5208840 - 906 WP_258643286.1 LysR family transcriptional regulator -
LOY51_RS23465 (LOY51_23425) 5208986..5209576 - 591 WP_258643288.1 NAD(P)H-dependent oxidoreductase -
LOY51_RS23470 (LOY51_23430) 5209754..5210068 + 315 WP_125465616.1 putative quinol monooxygenase -
LOY51_RS23475 (LOY51_23435) 5210058..5210822 - 765 WP_125860472.1 sulfite exporter TauE/SafE family protein -
LOY51_RS23480 (LOY51_23440) 5210900..5211784 + 885 WP_258643291.1 LysR family transcriptional regulator -
LOY51_RS23485 (LOY51_23445) 5211938..5212348 - 411 WP_125465619.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY51_RS23490 (LOY51_23450) 5212405..5212587 - 183 WP_125465620.1 type II toxin-antitoxin system HicA family toxin Toxin
LOY51_RS23495 (LOY51_23455) 5212801..5213406 + 606 WP_258643293.1 CDP-alcohol phosphatidyltransferase family protein -
LOY51_RS23500 (LOY51_23460) 5213437..5215191 + 1755 WP_125860480.1 bifunctional alpha/beta hydrolase/class I SAM-dependent methyltransferase -
LOY51_RS23505 (LOY51_23465) 5215191..5216594 + 1404 WP_125860482.1 phosphatase PAP2/dual specificity phosphatase family protein -
LOY51_RS23510 (LOY51_23470) 5216591..5217010 + 420 WP_125860483.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6942.97 Da        Isoelectric Point: 10.7251

>T225051 WP_125465620.1 NZ_CP087185:c5212587-5212405 [Pseudomonas sichuanensis]
MRSRDVIQLIEADGWYEVEVKGSHHQFRHPYKRGRVTVPHPKSDLPRGTVHSILKQAGLK

Download         Length: 183 bp

>T225051 NZ_CP120942:c4441239-4439920 [Aeromonas caviae]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGAGTCATGGCTAGCACAACCGGGCAGCCGTCCGATCTCACTCTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGAAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACCCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGATGTTCCAGATGTCAGGCGAATCGACTACAAGGCACTTTCCGATGACGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGGGCGCAAGAAAAGACTGCG
CTGCTCTATATCGATGGCCGTTGGTACTTGCCACTCAAAGCAACGCCGACAACCCACATTATCAAACTCCCTATCGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATAATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGCCATGGAGGACCAGGGATCACAGACATCATGAAAACCTTGCTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCAGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGGCGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGTGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAGTACTCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCAAAAACTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGCGTTACCCAGCAATTGCCAGCAGACTTCCCCGATACCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGTTGGGATTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14723.62 Da        Isoelectric Point: 4.6138

>AT225051 WP_125465619.1 NZ_CP087185:c5212348-5211938 [Pseudomonas sichuanensis]
MKFPVVLHKDEGSDYGVIVPDVPGCFSAGATVSQALENVQEALALHFEGLVADGEALPQAEEVDVHVANPDYAGGVWAVV
DFDVTPYLGKAVRFNATLPENLLQRIDEKVKRDHRYASRSGFLASAALRELAVAFR

Download         Length: 411 bp

>AT225051 NZ_CP120942:c4441493-4441239 [Aeromonas caviae]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAGCTCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCAGCACTCGAATTGTCAGTGGATATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References