Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4803295..4803979 Replicon chromosome
Accession NZ_CP087185
Organism Pseudomonas sichuanensis strain B21-027

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag LOY51_RS21710 Protein ID WP_258643011.1
Coordinates 4803295..4803666 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag LOY51_RS21715 Protein ID WP_125860088.1
Coordinates 4803659..4803979 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY51_RS21680 (LOY51_21640) 4798785..4799510 + 726 WP_110993430.1 LPS export ABC transporter ATP-binding protein -
LOY51_RS21685 (LOY51_21645) 4799695..4801188 + 1494 WP_125860080.1 RNA polymerase factor sigma-54 -
LOY51_RS21690 (LOY51_21650) 4801267..4801575 + 309 WP_110993432.1 ribosome-associated translation inhibitor RaiA -
LOY51_RS21695 (LOY51_21655) 4801588..4802052 + 465 WP_110993433.1 PTS IIA-like nitrogen regulatory protein PtsN -
LOY51_RS21700 (LOY51_21660) 4802055..4802909 + 855 WP_125860081.1 RNase adapter RapZ -
LOY51_RS21705 (LOY51_21665) 4802930..4803202 + 273 WP_125860083.1 HPr family phosphocarrier protein -
LOY51_RS21710 (LOY51_21670) 4803295..4803666 + 372 WP_258643011.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY51_RS21715 (LOY51_21675) 4803659..4803979 + 321 WP_125860088.1 helix-turn-helix transcriptional regulator Antitoxin
LOY51_RS21720 (LOY51_21680) 4803983..4804876 - 894 WP_125861410.1 ZIP family metal transporter -
LOY51_RS21725 (LOY51_21685) 4804888..4805499 - 612 WP_125860090.1 superoxide dismutase -
LOY51_RS21730 (LOY51_21690) 4805501..4805962 - 462 WP_125860092.1 hypothetical protein -
LOY51_RS21735 (LOY51_21695) 4805988..4807364 - 1377 WP_125860094.1 class II fumarate hydratase -
LOY51_RS21740 (LOY51_21700) 4807357..4807758 - 402 WP_125860096.1 FagA protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-111)

Antitoxin

HigA2-like, helix-turn-helix domain

(11-90)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13742.65 Da        Isoelectric Point: 9.7292

>T225050 WP_258643011.1 NZ_CP087185:4803295-4803666 [Pseudomonas sichuanensis]
MEAIKNVKRLFWVGSSRKDIQALPADVQDVFGFALYQAQEGGKHWQAKVLKGFSGGGVLEVVEDHHGDTYRAVYTISLVD
AVYVLHCFQQKSRSGIKTSRHDVDLIHARLKLAQAHSKGKTHD

Download         Length: 372 bp

>T225050 NZ_CP120942:c2171301-2171050 [Aeromonas caviae]
ATGGACGCTATCACTTACACACACGCCCGCGCCAACCTGGCTGGAACCATGGATCGTGTTTGCAACGATCATGAGCCGGT
GATCATCACACGTAACGGCGACCAATCGGTTGTGATTCTCTCGCTGGAAGATTTCCAGGCGCTGGAAGAAACTGCGTATC
TGCTGCGCAGCCCCGCCAACGCCAAGCGGCTTTTCAAGTCGATCGAGCAACTTGAAGCGGGCCGAGGACAGGCGCGGGAG
TTGGCCGAATGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11669.71 Da        Isoelectric Point: 8.2760

>AT225050 WP_125860088.1 NZ_CP087185:4803659-4803979 [Pseudomonas sichuanensis]
MIEIEEGTDNVYADLHLADASEMLVKACLASKICSIIKARQLTQLQAAELLGLSQPKVSALTRGKFRGISESKMIDCLAR
LGRDIQIVVKEAPKTRREGRVEVIFA

Download         Length: 321 bp

>AT225050 NZ_CP120942:c2171053-2170799 [Aeromonas caviae]
ATGAGATTAATTTTTTCCGATGATGCATGGGAAGATTATCTGTTCTGGCAAAAACAAGACCGCCGCATGGTTGATCGAAT
TAACAAGCTAATTAAAGAAACCACCCGAGAGCCTTTCTCTGGAGTGGGCAAGCCAGAGCCATTAAAACATGCTTTGGCCG
GTTATTGGTCTCGTCGAATTACGGATGAGCACCGAATGGTTTACAAAGTGGCGGATGATGCCCTTTGGATCGTTCAACTC
AAGTACCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References