Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 44638..45199 Replicon plasmid P5
Accession NZ_CP087071
Organism Pseudosulfitobacter pseudonitzschiae strain MC36-22

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LOE34_RS22680 Protein ID WP_224557555.1
Coordinates 44638..44913 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LOE34_RS22685 Protein ID WP_224557554.1
Coordinates 44906..45199 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE34_RS22665 (LOE34_22660) 40427..41743 - 1317 WP_224557560.1 lactate racemase domain-containing protein -
LOE34_RS22670 (LOE34_22665) 41760..43307 - 1548 WP_224557559.1 altronate dehydratase family protein -
LOE34_RS22675 (LOE34_22670) 43399..44169 + 771 WP_224557557.1 GntR family transcriptional regulator -
LOE34_RS22680 (LOE34_22675) 44638..44913 - 276 WP_224557555.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOE34_RS22685 (LOE34_22680) 44906..45199 - 294 WP_224557554.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LOE34_RS22690 (LOE34_22685) 45270..46175 - 906 WP_224557552.1 dihydrodipicolinate synthase family protein -
LOE34_RS22695 (LOE34_22690) 46186..47925 - 1740 WP_224557550.1 L-arabinonate dehydratase -
LOE34_RS22700 (LOE34_22695) 48187..49722 + 1536 WP_224557548.1 aldehyde dehydrogenase (NADP(+)) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..82230 82230


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-55)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10108.67 Da        Isoelectric Point: 4.4912

>T224693 WP_224557555.1 NZ_CP087071:c44913-44638 [Pseudosulfitobacter pseudonitzschiae]
VPDLEWKALAVADLMAIVDYISDDNPDAAISLMDDIQDKVLGLLTHPKSGRPGRVNDTRELVIRPNYIVVYAENTAAVTI
LRVLHAVQMWP

Download         Length: 276 bp

>T224693 NZ_CP120395:c4676464-4676090 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAAAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAACGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
CAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10166.59 Da        Isoelectric Point: 7.2024

>AT224693 WP_224557554.1 NZ_CP087071:c45199-44906 [Pseudosulfitobacter pseudonitzschiae]
MSAQTSMIHVRVDDQLKAKATDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTANPDAYDAWFRAKVQDALADAAPAKPH
DQVMRDARALIDGKRGA

Download         Length: 294 bp

>AT224693 NZ_CP120395:c4676706-4676464 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References