Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1337350..1337930 Replicon chromosome
Accession NZ_CP087025
Organism Pseudosulfitobacter pseudonitzschiae strain MC52-68

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE44_RS06650 Protein ID WP_224556587.1
Coordinates 1337350..1337604 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE44_RS06655 Protein ID WP_224556600.1
Coordinates 1337601..1337930 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE44_RS06605 (LOE44_06600) 1332805..1333053 + 249 WP_229940863.1 hypothetical protein -
LOE44_RS06610 (LOE44_06605) 1333616..1334158 + 543 WP_229940519.1 hypothetical protein -
LOE44_RS06615 (LOE44_06610) 1334373..1334696 + 324 WP_224556571.1 hypothetical protein -
LOE44_RS06620 (LOE44_06615) 1334774..1335289 - 516 WP_224556573.1 hypothetical protein -
LOE44_RS06625 (LOE44_06620) 1335267..1336094 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE44_RS06630 (LOE44_06625) 1336091..1336252 - 162 WP_224556578.1 hypothetical protein -
LOE44_RS06635 (LOE44_06630) 1336252..1336704 - 453 WP_224556581.1 hypothetical protein -
LOE44_RS06640 (LOE44_06635) 1336780..1336950 - 171 WP_224556583.1 hypothetical protein -
LOE44_RS06645 (LOE44_06640) 1337050..1337238 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE44_RS06650 (LOE44_06645) 1337350..1337604 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE44_RS06655 (LOE44_06650) 1337601..1337930 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE44_RS06660 (LOE44_06655) 1337991..1338254 + 264 WP_224556602.1 hypothetical protein -
LOE44_RS23730 1338241..1338363 - 123 WP_263481010.1 hypothetical protein -
LOE44_RS06665 (LOE44_06660) 1338356..1338646 - 291 WP_224556604.1 hypothetical protein -
LOE44_RS06670 (LOE44_06665) 1338709..1339233 - 525 WP_224556606.1 hypothetical protein -
LOE44_RS06675 (LOE44_06670) 1339453..1340376 - 924 WP_229940510.1 phage minor head protein -
LOE44_RS06680 (LOE44_06675) 1340498..1340662 - 165 WP_229940508.1 hypothetical protein -
LOE44_RS06685 (LOE44_06680) 1340659..1341075 - 417 WP_229940505.1 hypothetical protein -
LOE44_RS06690 (LOE44_06685) 1341072..1341377 - 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE44_RS06695 (LOE44_06690) 1341374..1341628 - 255 WP_224556623.1 hypothetical protein -
LOE44_RS06700 (LOE44_06695) 1341625..1341783 - 159 WP_224556625.1 hypothetical protein -
LOE44_RS06705 (LOE44_06700) 1341780..1341968 - 189 WP_224556628.1 hypothetical protein -
LOE44_RS06710 (LOE44_06705) 1341968..1342858 - 891 WP_229940766.1 RNA ligase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1319658..1357171 37513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224659 WP_224556587.1 NZ_CP087025:1337350-1337604 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224659 NZ_CP120393:204780-205265 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGACGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224659 WP_224556600.1 NZ_CP087025:1337601-1337930 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224659 NZ_CP120393:204505-204792 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAGTCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References