Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 92562..93236 Replicon plasmid P6
Accession NZ_CP086985
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-111

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE09_RS23390 Protein ID WP_224557924.1
Coordinates 92814..93236 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOE09_RS23385 Protein ID WP_229939240.1
Coordinates 92562..92810 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE09_RS23365 (LOE09_23355) 88475..89119 + 645 WP_224557929.1 type IV secretion system protein -
LOE09_RS23370 (LOE09_23360) 89123..89854 + 732 WP_224557928.1 TrbG/VirB9 family P-type conjugative transfer protein -
LOE09_RS23375 (LOE09_23365) 89857..91314 + 1458 WP_224557927.1 TrbI/VirB10 family protein -
LOE09_RS23380 (LOE09_23370) 91425..92414 + 990 WP_224557926.1 P-type DNA transfer ATPase VirB11 -
LOE09_RS23385 (LOE09_23375) 92562..92810 + 249 WP_229939240.1 plasmid stabilization protein Antitoxin
LOE09_RS23390 (LOE09_23380) 92814..93236 + 423 WP_224557924.1 type II toxin-antitoxin system VapC family toxin Toxin
LOE09_RS23395 (LOE09_23385) 93233..95983 + 2751 WP_224557923.1 lactate dehydrogenase -
LOE09_RS23400 (LOE09_23390) 95980..97038 + 1059 WP_224557922.1 HEPN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..157665 157665


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15255.26 Da        Isoelectric Point: 4.3767

>T224628 WP_224557924.1 NZ_CP086985:92814-93236 [Pseudosulfitobacter pseudonitzschiae]
MIILDTNVICELLRPTPEPRIEQWLSAQDGLNVYLTSISEAELRYGLANMGNGKRRAALIDAVDRILREDLAGRILPFDS
DAAQAYASIAATRRDAGRPIAQADCQIASIAHACGATVATRNTPDFEGCEIDLINPWTTE

Download         Length: 423 bp

>T224628 NZ_CP120369:601418-601825 [Sinorhizobium numidicum]
ATGTATCTGGTTGACACCAACATCGTCTCGGAGGCGCGACGCGGCGCGCCGCAGGCGGTTGCCTGGCTGCGCTCGGTCGA
CCCGCTCAGCATCCATCTGAGCGCGCTGACCCTCGGCGAAATCATGCGCGGCATTGCGCTGAAACAGAAGTCGGATCCGA
AGGCCGCCGCTCACCTCGCCGAATGGCTGCGCAAGCTGCGCCACGACCACGGCGACCGTATCCTGCCGGTGACCGACCAG
ATCGCCGTCGAATGGGGCCGCATCGCCGCGATCCGACCGCGTGGCGATATTGACGGGCTCCTCGCCGCGACTGCGGTCGT
CCACGACCTGATCCTCGTCACGCGCAACGTCAAGGATTTTGAAGACACGGACGCTTCCGTGATCAATCCGTGGGAGACAC
CGGCGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9206.46 Da        Isoelectric Point: 6.7281

>AT224628 WP_229939240.1 NZ_CP086985:92562-92810 [Pseudosulfitobacter pseudonitzschiae]
MASITIRNLDDDVKRRLRIRAAEHGRSMEEEAREILRQVVGDAKPNHDLAAAIRARVGPLGGVELDLPQREAMHEPPTFD
RA

Download         Length: 249 bp

>AT224628 NZ_CP120369:601164-601418 [Sinorhizobium numidicum]
ATGGAATGGCAGCTGCAGGACGCCAAGAACCACTTCTCGAAAGTGGTGCAGAAGGCGCGACACGAGGGGCCGCAGATCGT
CACGCTGCGTGGCGAGCGCACGGCCGTAGTGCTGTCCGCCCACGACTATGACGCTCTGCGCGCCGGCCGACCGACGCTGG
TCGACGATCTGCTCGGCGGTCCCCCTTGGGACGATGAGCTCGCCGATGCGGTCGAGGCGCGCGCCAAGACGCCAAGCCGC
GACGTGGCCTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References