Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 23777..24389 Replicon plasmid P1
Accession NZ_CP086980
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-111

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOE09_RS19385 Protein ID WP_028288627.1
Coordinates 23994..24389 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A921TG38
Locus tag LOE09_RS19380 Protein ID WP_009503866.1
Coordinates 23777..24004 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE09_RS19365 (LOE09_19360) 20034..21245 - 1212 WP_050525470.1 plasmid replication protein RepC -
LOE09_RS19370 (LOE09_19365) 21459..22391 - 933 WP_028288626.1 plasmid partitioning protein RepB -
LOE09_RS19375 (LOE09_19370) 22375..23568 - 1194 WP_009503867.1 plasmid partitioning protein RepA -
LOE09_RS19380 (LOE09_19375) 23777..24004 + 228 WP_009503866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LOE09_RS19385 (LOE09_19380) 23994..24389 + 396 WP_028288627.1 PIN domain-containing protein Toxin
LOE09_RS19390 (LOE09_19385) 24468..24959 - 492 Protein_25 recombinase family protein -
LOE09_RS19395 (LOE09_19390) 25061..26200 - 1140 WP_229940649.1 tyrosine-type recombinase/integrase -
LOE09_RS19400 (LOE09_19395) 26327..27211 + 885 WP_037239259.1 DUF1403 family protein -
LOE09_RS19405 (LOE09_19400) 27259..27870 + 612 WP_197919471.1 SMC-Scp complex subunit ScpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..111867 111867


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Antitoxin PemI-like

(2-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14212.23 Da        Isoelectric Point: 4.1653

>T224625 WP_028288627.1 NZ_CP086980:23994-24389 [Pseudosulfitobacter pseudonitzschiae]
MSVEFADTNVVLYLLDDGPKADRAEVILGQGPRISVQVLNESLVNCRRKAGLGWEEAAAFLEGVRALCPVEDLTVQTHDV
GRALAERYGFSIYDAMIVASALVAGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T224625 NZ_CP120367:c2203239-2202964 [Sinorhizobium numidicum]
ATGAAGCTTGAGTGGTCGAGTAAAGCGGTGTCCGATCTCGGGCGCCTCTATGATTTCCTGGCGCTAGTAAATCGGCAAGC
CGCTGTCCGCACCGTCCAATCTTTGACAAGCGCTCCAACAAGCCTGCTTGAACAACCATGGATCGGCGAGCGGCTGGAGG
AGTTCAATCCCCGCGAGGTCCGCCGAATCGTCGTTGGCCATTACGAAATGCGCTATGAGATCAGGCAGTCAACGATCTAC
GTGCTGCGGCTTTGGCATACGCGTGAAGAGCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8535.79 Da        Isoelectric Point: 11.0482

>AT224625 WP_009503866.1 NZ_CP086980:23777-24004 [Pseudosulfitobacter pseudonitzschiae]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGRVRVRRLARADEVLTGLRRFRGKLSAAERLSRDDAHER

Download         Length: 228 bp

>AT224625 NZ_CP120367:c2203499-2203239 [Sinorhizobium numidicum]
ATGGAAACGAAGGTAGTGACAGCGCACGTGCCCCTGCCGCTCGCCGAAAAAGTCGATCAGATCGCGGCTCGACTTGAGCG
TTCGCGCGGTTGGATCGTGAAGCAAGCGCTGGCGGCCTGGATCGACCAGGAAGAGGAACGCCGGCGCATGACTCTGGAGG
CGCTCGCTGACGTGGACAGTGGCCGGGTGATTGACCATCAGTCCGTGCAGGCGTGGGCCGACAGTCTCGACAGCGACAAG
CCGCGGCCGCTACCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References