Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1833967..1834547 Replicon chromosome
Accession NZ_CP086979
Organism Pseudosulfitobacter pseudonitzschiae strain SC1-111

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE09_RS08950 Protein ID WP_224556587.1
Coordinates 1833967..1834221 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE09_RS08955 Protein ID WP_224556600.1
Coordinates 1834218..1834547 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE09_RS08905 (LOE09_08900) 1829422..1829670 + 249 WP_229940863.1 hypothetical protein -
LOE09_RS08910 (LOE09_08905) 1830233..1830775 + 543 WP_229940519.1 hypothetical protein -
LOE09_RS08915 (LOE09_08910) 1830990..1831313 + 324 WP_224556571.1 hypothetical protein -
LOE09_RS08920 (LOE09_08915) 1831391..1831906 - 516 WP_224556573.1 hypothetical protein -
LOE09_RS08925 (LOE09_08920) 1831884..1832711 - 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE09_RS08930 (LOE09_08925) 1832708..1832869 - 162 WP_224556578.1 hypothetical protein -
LOE09_RS08935 (LOE09_08930) 1832869..1833321 - 453 WP_224556581.1 hypothetical protein -
LOE09_RS08940 (LOE09_08935) 1833397..1833567 - 171 WP_224556583.1 hypothetical protein -
LOE09_RS08945 (LOE09_08940) 1833667..1833855 + 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE09_RS08950 (LOE09_08945) 1833967..1834221 + 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE09_RS08955 (LOE09_08950) 1834218..1834547 + 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE09_RS08960 (LOE09_08955) 1834608..1834871 + 264 WP_224556602.1 hypothetical protein -
LOE09_RS23745 1834858..1834980 - 123 WP_263481010.1 hypothetical protein -
LOE09_RS08965 (LOE09_08960) 1834973..1835263 - 291 WP_224556604.1 hypothetical protein -
LOE09_RS08970 (LOE09_08965) 1835326..1835850 - 525 WP_224556606.1 hypothetical protein -
LOE09_RS08975 (LOE09_08970) 1836394..1836558 - 165 WP_229940508.1 hypothetical protein -
LOE09_RS08980 (LOE09_08975) 1836555..1836971 - 417 WP_229940505.1 hypothetical protein -
LOE09_RS08985 (LOE09_08980) 1836968..1837273 - 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE09_RS08990 (LOE09_08985) 1837270..1837524 - 255 WP_224556623.1 hypothetical protein -
LOE09_RS08995 (LOE09_08990) 1837521..1837679 - 159 WP_224556625.1 hypothetical protein -
LOE09_RS09000 (LOE09_08995) 1837676..1837864 - 189 WP_224556628.1 hypothetical protein -
LOE09_RS09005 (LOE09_09000) 1837864..1838751 - 888 WP_224556631.1 RNA ligase family protein -
LOE09_RS09010 (LOE09_09005) 1838751..1839113 - 363 WP_224556633.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1816275..1853067 36792


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224623 WP_224556587.1 NZ_CP086979:1833967-1834221 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224623 NZ_CP120367:c299618-299235 [Sinorhizobium numidicum]
GTGAGGCTGGCCGACACGGGAATCTGGATCGACCACTTCCGCCTAGCTGATCCGCAGCTAATCCAAACGATCGAAAACGA
TATGCTGCTCTGCCATCCCGCCATCGTTGGCGAACTTGCGTTGGGCAGCTTGCACAATCGTCTGGTCACGCTCGGGTTCT
TGGCGGTCCAACGGGAGGTCATCATCGCCACGCACGATGAAGTCATGGCAATGATCGACGAGCACCAACTTTACAGCATG
GGCATAGGCTACACGGACGCCCATCTGCTCGCGTCAACTTTAATCGACAGCCGAGCCGAGTTGTGGACGCGAGACAAGCG
GCTGCGCAGGGCGGCAGAAAAAGCGCGCGCGCGGGTGGTTTCTGACGGTACTGTGCCCAACTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224623 WP_224556600.1 NZ_CP086979:1834218-1834547 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224623 NZ_CP120367:c299809-299615 [Sinorhizobium numidicum]
ATGCGGTCAACCATCAACATAGACGACAGCCTCATGGAAAAGGCGAAGGCCCTGACCGGCACGAAAGAAACGGCGGCGGT
CGTCCGTCAGGCGCTGGAAACGCTGGTTCGCATGGAAGCAGGCAAGCGTCTGATCGCCTTGGGCGGCACGATGCCCGACG
CGGAGGCTGGTCCGCGGAGGCGGGCCGAAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References