Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PemK-MazE |
| Location | 22093..22634 | Replicon | plasmid P5 |
| Accession | NZ_CP086959 | ||
| Organism | Pseudosulfitobacter pseudonitzschiae strain SC1-27 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | A0A073IW87 |
| Locus tag | LOE13_RS21575 | Protein ID | WP_037931244.1 |
| Coordinates | 22093..22419 (-) | Length | 109 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | A0A073IWP4 |
| Locus tag | LOE13_RS21580 | Protein ID | WP_037931247.1 |
| Coordinates | 22416..22634 (-) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOE13_RS21545 (LOE13_21535) | 17387..17884 | - | 498 | WP_037931962.1 | DUF5519 family protein | - |
| LOE13_RS21550 (LOE13_21540) | 17893..18708 | - | 816 | WP_224556226.1 | class III extradiol ring-cleavage dioxygenase | - |
| LOE13_RS21555 (LOE13_21545) | 18772..19167 | - | 396 | WP_037931981.1 | DoxX family protein | - |
| LOE13_RS21560 (LOE13_21550) | 19342..19665 | + | 324 | WP_027238707.1 | helix-turn-helix domain-containing protein | - |
| LOE13_RS21565 (LOE13_21555) | 20001..21573 | + | 1573 | Protein_24 | IS21 family transposase | - |
| LOE13_RS21570 (LOE13_21560) | 21563..21919 | + | 357 | Protein_25 | ATP-binding protein | - |
| LOE13_RS21575 (LOE13_21565) | 22093..22419 | - | 327 | WP_037931244.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LOE13_RS21580 (LOE13_21570) | 22416..22634 | - | 219 | WP_037931247.1 | antitoxin MazE family protein | Antitoxin |
| LOE13_RS21585 (LOE13_21575) | 22932..24065 | - | 1134 | WP_037931249.1 | alpha/beta fold hydrolase | - |
| LOE13_RS21590 (LOE13_21580) | 24069..24533 | - | 465 | WP_051694690.1 | MaoC/PaaZ C-terminal domain-containing protein | - |
| LOE13_RS21595 (LOE13_21585) | 24588..26135 | - | 1548 | WP_073194592.1 | AMP-binding protein | - |
| LOE13_RS21600 (LOE13_21590) | 26370..27377 | - | 1008 | WP_081855484.1 | PaaX family transcriptional regulator C-terminal domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..193372 | 193372 | |
| - | flank | IS/Tn | - | - | 20287..21573 | 1286 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 109 a.a. Molecular weight: 11610.50 Da Isoelectric Point: 8.8545
>T224607 WP_037931244.1 NZ_CP086959:c22419-22093 [Pseudosulfitobacter pseudonitzschiae]
VRRGELVTVALQGDHGKPRPALVIQSDRFPDTATTTVLLVTSTLVDAPLIRLTVEPSAENGLRMRSQIMIDKAVTVRTDK
LGKAFGQLDDTAMIEVNRALALFLGVAG
VRRGELVTVALQGDHGKPRPALVIQSDRFPDTATTTVLLVTSTLVDAPLIRLTVEPSAENGLRMRSQIMIDKAVTVRTDK
LGKAFGQLDDTAMIEVNRALALFLGVAG
Download Length: 327 bp
>T224607 NZ_CP120364:1496343-1496897 [Sinorhizobium kummerowiae]
ATGGGGAAACACATTCCGCCCGCATCGCGACCCGATCCGGAACTGACGCCGTCGGTCGAGCGGATAACGCTCTGGCGCGC
CTTCGTTCCACGCTGGGCGCATATGCCGTTATCCGGCGCGGGTGCCGCTCGCTTCGGTGGCCGCTGGAATCCCATCGGCG
TGCCTGCGATTTATGGTGCGCGCGAACTCTCCACCGCCTGGGCTGAATATAACCAGGGTTTCGTCCAGCATCCGGCGCTC
ATCGTGCAGCTCGAGTTGCGCGGGGCGAAGCTCGCGGACCTCACGGATGCCAGCGTTCTTCTGGGGCTTGGTGTGGATGA
GGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAAGGCGCGGTGCCGGAGACCCACAGGCTCCAGTCGGATCTTC
TGGCGCGCGACTATCACGGGGTGATCTATCCATCCTTCATGTCGCCCGGGGGCACCTGCGTCGCGCTCTGGCGCTGGAAC
GGTCCGGAAGAACCGCGTCTCGACGTCATCGATCCCGATGGCCGGCTGCCGAAATCCCCCGCCTCATGGGTTTGA
ATGGGGAAACACATTCCGCCCGCATCGCGACCCGATCCGGAACTGACGCCGTCGGTCGAGCGGATAACGCTCTGGCGCGC
CTTCGTTCCACGCTGGGCGCATATGCCGTTATCCGGCGCGGGTGCCGCTCGCTTCGGTGGCCGCTGGAATCCCATCGGCG
TGCCTGCGATTTATGGTGCGCGCGAACTCTCCACCGCCTGGGCTGAATATAACCAGGGTTTCGTCCAGCATCCGGCGCTC
ATCGTGCAGCTCGAGTTGCGCGGGGCGAAGCTCGCGGACCTCACGGATGCCAGCGTTCTTCTGGGGCTTGGTGTGGATGA
GGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAAGGCGCGGTGCCGGAGACCCACAGGCTCCAGTCGGATCTTC
TGGCGCGCGACTATCACGGGGTGATCTATCCATCCTTCATGTCGCCCGGGGGCACCTGCGTCGCGCTCTGGCGCTGGAAC
GGTCCGGAAGAACCGCGTCTCGACGTCATCGATCCCGATGGCCGGCTGCCGAAATCCCCCGCCTCATGGGTTTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8175.17 Da Isoelectric Point: 5.8017
>AT224607 WP_037931247.1 NZ_CP086959:c22634-22416 [Pseudosulfitobacter pseudonitzschiae]
MPTSVSHRVQKRRDALRAAGLRPVQIWVPDTRRPGFEAECRRQAAIVAKADRADDTLNDFLDASLVDVDDWE
MPTSVSHRVQKRRDALRAAGLRPVQIWVPDTRRPGFEAECRRQAAIVAKADRADDTLNDFLDASLVDVDDWE
Download Length: 219 bp
>AT224607 NZ_CP120364:1495965-1496336 [Sinorhizobium kummerowiae]
ATAATGGCCGTCGATTTCCAGATACCTGCAGCCCGTTTCGGAGACGATCATTCCCCGTTTCTCTCGGCCCGCCTTGTCGC
CGACCGGTTGGGCGTCACACTCGCCGAACTCGCGAAGCTGATCGGTGTCGCCCGCAATACGCTGACGGCGAAGTCCGGCG
CCCGAAAGGTGGACAGCGCCTTAAGCAAGGTGGTCCGCATCCTCGCCATGGCTTCGGAAATGGCGGGCGACGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATCCCCGGCTGGGCAGGCAAGACGGCATTCGACCTGGTCGGCGAGGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGTGCCGGCGTCTACGCCTAA
ATAATGGCCGTCGATTTCCAGATACCTGCAGCCCGTTTCGGAGACGATCATTCCCCGTTTCTCTCGGCCCGCCTTGTCGC
CGACCGGTTGGGCGTCACACTCGCCGAACTCGCGAAGCTGATCGGTGTCGCCCGCAATACGCTGACGGCGAAGTCCGGCG
CCCGAAAGGTGGACAGCGCCTTAAGCAAGGTGGTCCGCATCCTCGCCATGGCTTCGGAAATGGCGGGCGACGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATCCCCGGCTGGGCAGGCAAGACGGCATTCGACCTGGTCGGCGAGGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGTGCCGGCGTCTACGCCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A073IW87 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A073IWP4 |