Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2025076..2025656 Replicon chromosome
Accession NZ_CP086798
Organism Pseudosulfitobacter pseudonitzschiae strain TT37-47

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOE37_RS10365 Protein ID WP_224556587.1
Coordinates 2025402..2025656 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOE37_RS10360 Protein ID WP_224556600.1
Coordinates 2025076..2025405 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE37_RS10305 (LOE37_10305) 2020151..2021038 + 888 WP_224556631.1 RNA ligase family protein -
LOE37_RS10310 (LOE37_10310) 2021038..2021226 + 189 WP_224556628.1 hypothetical protein -
LOE37_RS10315 (LOE37_10315) 2021223..2021381 + 159 WP_224556625.1 hypothetical protein -
LOE37_RS10320 (LOE37_10320) 2021378..2021632 + 255 WP_224556623.1 hypothetical protein -
LOE37_RS10325 (LOE37_10325) 2021629..2021934 + 306 WP_224556620.1 helix-turn-helix domain-containing protein -
LOE37_RS10330 (LOE37_10330) 2021931..2022347 + 417 WP_229940505.1 hypothetical protein -
LOE37_RS10335 (LOE37_10335) 2022344..2022508 + 165 WP_229940508.1 hypothetical protein -
LOE37_RS10340 (LOE37_10340) 2022630..2023553 + 924 WP_229940510.1 phage minor head protein -
LOE37_RS10345 (LOE37_10345) 2023773..2024297 + 525 WP_224556606.1 hypothetical protein -
LOE37_RS10350 (LOE37_10350) 2024360..2024650 + 291 WP_224556604.1 hypothetical protein -
LOE37_RS23750 2024643..2024765 + 123 WP_263481010.1 hypothetical protein -
LOE37_RS10355 (LOE37_10355) 2024752..2025015 - 264 WP_224556602.1 hypothetical protein -
LOE37_RS10360 (LOE37_10360) 2025076..2025405 - 330 WP_224556600.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOE37_RS10365 (LOE37_10365) 2025402..2025656 - 255 WP_224556587.1 type II toxin-antitoxin system HicA family toxin Toxin
LOE37_RS10370 (LOE37_10370) 2025768..2025956 - 189 WP_224556585.1 ribbon-helix-helix domain-containing protein -
LOE37_RS10375 (LOE37_10375) 2026056..2026226 + 171 WP_224556583.1 hypothetical protein -
LOE37_RS10380 (LOE37_10380) 2026302..2026754 + 453 WP_224556581.1 hypothetical protein -
LOE37_RS10385 (LOE37_10385) 2026754..2026915 + 162 WP_224556578.1 hypothetical protein -
LOE37_RS10390 (LOE37_10390) 2026912..2027739 + 828 WP_224556575.1 ParB N-terminal domain-containing protein -
LOE37_RS10395 (LOE37_10395) 2027717..2028232 + 516 WP_224556573.1 hypothetical protein -
LOE37_RS10400 (LOE37_10400) 2028310..2028633 - 324 WP_224556571.1 hypothetical protein -
LOE37_RS10405 (LOE37_10405) 2028848..2029390 - 543 WP_229940519.1 hypothetical protein -
LOE37_RS10410 (LOE37_10410) 2029953..2030201 - 249 WP_229940863.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2007275..2043896 36621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-82)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.69 Da        Isoelectric Point: 10.8025

>T224477 WP_224556587.1 NZ_CP086798:c2025656-2025402 [Pseudosulfitobacter pseudonitzschiae]
MNSKQRKTLKAIFTDPVSGTIEWVRIESLLVAAGAETIEGNGSRVRFVKDGVVGSFHRPHPDKEAKRYQVRDARAFLTQI
GVTP

Download         Length: 255 bp

>T224477 NZ_CP120334:14788-15120 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGACAGAGGGGAAATCTGGCTCGTCTCACTGGATCCTACAGCCGGACATGAACAAAGCGGAAAACGTCCGGTACTTAT
CGTTTCTCCGGCATCATTTAATAAGTTCACCCGGTTACCCGTTGTCGTTCCCGTCACCAGCGGCGGAGACTTTGCCCGCA
CAGCCGGTTTTACCGTCTCCCTGGACGGCGCGGGAACAAAAACAACGGGTGTTATTCGCTGCGACCAGCCCAGAACGATT
GATATGGGTGCCCGGAATGGTAAGCGTCTGGAACGTATACCCGAAGCTGTCGTAAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12090.66 Da        Isoelectric Point: 6.0876

>AT224477 WP_224556600.1 NZ_CP086798:c2025405-2025076 [Pseudosulfitobacter pseudonitzschiae]
MSTMTFKGYQARVEFDPEDEIFFGRIAGINDVVGFHGESVAELKSAFHEAVDDYLETCKAAGKKPQKPYSGKVMFRVAPE
THRRIAVAAELSGKSLNQWAEEKLEAAAH

Download         Length: 330 bp

>AT224477 NZ_CP120334:14530-14787 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGTATACCACTCGTCTGAAAAAGGTTGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGCTCT
GTCGACAGACAGCGAAGTGGGAATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCACAGTGCGATCCGCACGCCGAAATGAGCGATGAGGATAGGGAATGGATGGATGCGCCTGCAGTG
GGTAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References