Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 40348..40949 | Replicon | plasmid pE2 |
| Accession | NZ_CP086663 | ||
| Organism | Escherichia coli strain E2 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | LOE88_RS23415 | Protein ID | WP_033551393.1 |
| Coordinates | 40348..40728 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | LOE88_RS23420 | Protein ID | WP_001190712.1 |
| Coordinates | 40728..40949 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOE88_RS23370 (LOE88_23365) | 35740..35949 | + | 210 | WP_000874156.1 | hypothetical protein | - |
| LOE88_RS23375 (LOE88_23370) | 36060..36911 | + | 852 | WP_000611664.1 | phage repressor protein C1 | - |
| LOE88_RS23380 (LOE88_23375) | 36944..37276 | - | 333 | WP_224205061.1 | phage antirepressor KilAC domain-containing protein | - |
| LOE88_RS23385 (LOE88_23380) | 37397..37747 | - | 351 | Protein_45 | ORF6N domain-containing protein | - |
| LOE88_RS23390 (LOE88_23385) | 38056..38277 | - | 222 | WP_072019028.1 | host cell division inhibitor Icd-like protein | - |
| LOE88_RS23395 (LOE88_23390) | 38296..38415 | - | 120 | WP_001376634.1 | ash family protein | - |
| LOE88_RS23400 (LOE88_23395) | 38637..38969 | - | 333 | WP_033551395.1 | hypothetical protein | - |
| LOE88_RS23405 (LOE88_23400) | 39093..40136 | - | 1044 | WP_033551394.1 | DUF968 domain-containing protein | - |
| LOE88_RS23410 (LOE88_23405) | 40164..40343 | - | 180 | WP_000113018.1 | hypothetical protein | - |
| LOE88_RS23415 (LOE88_23410) | 40348..40728 | - | 381 | WP_033551393.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| LOE88_RS23420 (LOE88_23415) | 40728..40949 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LOE88_RS23425 (LOE88_23420) | 41132..41308 | + | 177 | Protein_53 | type I restriction-modification system subunit M N-terminal domain-containing protein | - |
| LOE88_RS23430 (LOE88_23425) | 41366..41772 | + | 407 | Protein_54 | IS1-like element IS1B family transposase | - |
| LOE88_RS23435 (LOE88_23430) | 41806..43557 | - | 1752 | Protein_55 | Tn3-like element TnAs1 family transposase | - |
| LOE88_RS23440 (LOE88_23435) | 43561..43953 | + | 393 | WP_001351729.1 | isochorismatase family cysteine hydrolase | - |
| LOE88_RS23445 (LOE88_23440) | 44091..44975 | + | 885 | WP_000058717.1 | EamA family transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | tet(A) / qnrS1 / dfrA14 / blaTEM-1C / floR | - | 1..94190 | 94190 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13559.26 Da Isoelectric Point: 5.6277
>T224317 WP_033551393.1 NZ_CP086663:c40728-40348 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGGISVSSVADTLRRLYGSSE
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGGISVSSVADTLRRLYGSSE
Download Length: 381 bp
>T224317 NZ_CP119984:c3655579-3655166 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT224317 WP_001190712.1 NZ_CP086663:c40949-40728 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT224317 NZ_CP119984:c3655826-3655560 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|