Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1872188..1873020 | Replicon | chromosome |
| Accession | NZ_CP086556 | ||
| Organism | Escherichia coli strain ESY002 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A7ZVJ9 |
| Locus tag | C5N07_RS08885 | Protein ID | WP_000854765.1 |
| Coordinates | 1872188..1872562 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | C5N07_RS08890 | Protein ID | WP_001295723.1 |
| Coordinates | 1872652..1873020 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C5N07_RS08845 (1867573) | 1867573..1867839 | - | 267 | WP_087757644.1 | EutP/PduV family microcompartment system protein | - |
| C5N07_RS08850 (1868209) | 1868209..1868598 | - | 390 | WP_001445118.1 | IS110 family transposase | - |
| C5N07_RS08855 (1868787) | 1868787..1869011 | - | 225 | Protein_1735 | transposase | - |
| C5N07_RS08860 (1869092) | 1869092..1869496 | + | 405 | WP_000839179.1 | transposase | - |
| C5N07_RS08865 (1869493) | 1869493..1869840 | + | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| C5N07_RS08870 (1869889) | 1869889..1871428 | + | 1540 | Protein_1738 | IS66-like element ISEc22 family transposase | - |
| C5N07_RS08875 (1871859) | 1871859..1871939 | - | 81 | Protein_1739 | hypothetical protein | - |
| C5N07_RS08880 (1872039) | 1872039..1872191 | - | 153 | Protein_1740 | DUF5983 family protein | - |
| C5N07_RS08885 (1872188) | 1872188..1872562 | - | 375 | WP_000854765.1 | TA system toxin CbtA family protein | Toxin |
| C5N07_RS08890 (1872652) | 1872652..1873020 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| C5N07_RS08895 (1873183) | 1873183..1873404 | - | 222 | WP_000692341.1 | DUF987 domain-containing protein | - |
| C5N07_RS08900 (1873467) | 1873467..1873943 | - | 477 | WP_001186774.1 | RadC family protein | - |
| C5N07_RS08905 (1873959) | 1873959..1874432 | - | 474 | WP_000855059.1 | antirestriction protein | - |
| C5N07_RS08910 (1874774) | 1874774..1875592 | - | 819 | WP_001234729.1 | DUF932 domain-containing protein | - |
| C5N07_RS08915 (1875710) | 1875710..1875905 | - | 196 | Protein_1747 | DUF905 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13970.98 Da Isoelectric Point: 7.2909
>T223799 WP_000854765.1 NZ_CP086556:c1872562-1872188 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T223799 NZ_CP119319:4414478-4414894 [Kluyvera intermedia]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCTCACAGTGGCTCTCTTTATTACTCCACGGTCTGGTGGCGGC
TTTTGTGCTGCTGATGCCGTGGCCGTTGAGCTACACCCCGCTTTGGCTGCTGTTGCTGTCACTGGTGGTATTTGACTGCG
TGCGCAGCCAACGGCGTATTCATTCGCACCAGGGGGAAATTAAACTGCTAATGGATTCCCGGCTGCGCTGGCGTAACCAG
GAGTGGGATATTCTGGGCACGCCGTGGATGCTGAGCTCAGGCATGATGTTACGGATTCGCCGCTGTGACGGTGGCCGACG
CCAGCATCTGTGGTTAGCGGCAGACAGTATGAATGCTCAGGAATGGCGCGACCTGCGGCGGATATTATTGCAGCAACCCG
CGCCAGGTCAGCATTAA
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCTCACAGTGGCTCTCTTTATTACTCCACGGTCTGGTGGCGGC
TTTTGTGCTGCTGATGCCGTGGCCGTTGAGCTACACCCCGCTTTGGCTGCTGTTGCTGTCACTGGTGGTATTTGACTGCG
TGCGCAGCCAACGGCGTATTCATTCGCACCAGGGGGAAATTAAACTGCTAATGGATTCCCGGCTGCGCTGGCGTAACCAG
GAGTGGGATATTCTGGGCACGCCGTGGATGCTGAGCTCAGGCATGATGTTACGGATTCGCCGCTGTGACGGTGGCCGACG
CCAGCATCTGTGGTTAGCGGCAGACAGTATGAATGCTCAGGAATGGCGCGACCTGCGGCGGATATTATTGCAGCAACCCG
CGCCAGGTCAGCATTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT223799 WP_001295723.1 NZ_CP086556:c1873020-1872652 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT223799 NZ_CP119319:4414231-4414497 [Kluyvera intermedia]
ATGGACATCAATAATAAAGCCCGTATCCACTGGGCATGCCGCCGAGGTATGCGTGAGCTCGACATCTCCATCATGCCGTT
TTTTGAGCATGAGTACGACACGCTGAGTGATGAAGACAAAACGGTCTTTATCCGTCTGCTGGAATGTGATGACCCGGACC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCTAATGCCGACTTCCAGCGTATGGTACAACTTATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATCAATAATAAAGCCCGTATCCACTGGGCATGCCGCCGAGGTATGCGTGAGCTCGACATCTCCATCATGCCGTT
TTTTGAGCATGAGTACGACACGCTGAGTGATGAAGACAAAACGGTCTTTATCCGTCTGCTGGAATGTGATGACCCGGACC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCTAATGCCGACTTCCAGCGTATGGTACAACTTATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|