Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3771873..3772546 Replicon chromosome
Accession NC_009719
Organism Parvibaculum lavamentivorans DS-1

Toxin (Protein)


Gene name vapC Uniprot ID A7HSF1
Locus tag PLAV_RS17875 Protein ID WP_012110102.1
Coordinates 3772124..3772546 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3XGK1
Locus tag PLAV_RS17870 Protein ID WP_012110103.1
Coordinates 3771873..3772127 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLAV_RS17860 3769474..3770508 + 1035 WP_012110105.1 toprim domain-containing protein -
PLAV_RS17865 3770860..3771786 + 927 WP_012110104.1 DUF2493 domain-containing protein -
PLAV_RS17870 3771873..3772127 + 255 WP_012110103.1 plasmid stabilization protein Antitoxin
PLAV_RS17875 3772124..3772546 + 423 WP_012110102.1 type II toxin-antitoxin system VapC family toxin Toxin
PLAV_RS19715 3772828..3772995 + 168 WP_012110101.1 hypothetical protein -
PLAV_RS17880 3773130..3773570 + 441 WP_012110100.1 hypothetical protein -
PLAV_RS17890 3774143..3774469 + 327 WP_041535876.1 DUF736 domain-containing protein -
PLAV_RS17895 3774777..3775043 + 267 WP_012110097.1 helix-turn-helix transcriptional regulator -
PLAV_RS17900 3775140..3775400 + 261 WP_012110096.1 DUF2285 domain-containing protein -
PLAV_RS17905 3775663..3776292 + 630 WP_083762510.1 DUF2285 domain-containing protein -
PLAV_RS17910 3776429..3776710 + 282 WP_012110094.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3638822..3896236 257414


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14928.09 Da        Isoelectric Point: 4.5093

>T22353 WP_012110102.1 NC_009719:3772124-3772546 [Parvibaculum lavamentivorans DS-1]
MILLDTNVVSEAMKPAPDEAVRAWLDEQAAETLFLSSVTIAELMFGIGALPDGKRKERLTEALDGVMELFADRVLPFDVD
AARRYADLAVKARAAGKGFPTPDGYIAAIAAAKGFAVATRDSSAFEAANVTVIDPWKAGR

Download         Length: 423 bp

>T22353 NC_009719:3772124-3772546 [Parvibaculum lavamentivorans DS-1]
ATGATCCTCCTCGACACCAATGTCGTATCGGAGGCGATGAAGCCCGCTCCCGACGAGGCCGTGCGCGCATGGCTCGACGA
GCAGGCGGCGGAAACACTCTTTCTCTCCAGCGTCACCATCGCCGAACTGATGTTCGGCATCGGCGCGCTCCCCGACGGCA
AGCGCAAGGAGCGTCTCACCGAAGCCCTGGATGGGGTGATGGAACTGTTCGCAGACCGCGTCCTCCCGTTCGATGTCGAT
GCTGCGCGCCGCTATGCGGATCTCGCCGTCAAAGCCCGAGCGGCCGGGAAAGGCTTCCCTACTCCCGACGGCTACATCGC
GGCGATTGCAGCCGCCAAGGGGTTTGCCGTCGCCACGCGCGACAGCAGCGCATTCGAGGCCGCGAATGTCACGGTGATCG
ATCCCTGGAAGGCCGGGCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9351.67 Da        Isoelectric Point: 10.4317

>AT22353 WP_012110103.1 NC_009719:3771873-3772127 [Parvibaculum lavamentivorans DS-1]
MPAVTIRNLSDATHRALKVRAAQHGRSAEAEMRDILEMAVRPDTRLRLGTALAERSRRLGLTNEDVEALDQARDKAPAKP
MSFE

Download         Length: 255 bp

>AT22353 NC_009719:3771873-3772127 [Parvibaculum lavamentivorans DS-1]
ATGCCCGCAGTTACGATCAGGAATCTGTCCGACGCGACGCATCGCGCCCTCAAGGTGCGGGCGGCGCAGCACGGCCGCAG
CGCCGAAGCGGAAATGCGCGACATCCTCGAAATGGCTGTCCGCCCCGATACGCGCCTCCGGCTCGGCACGGCGCTCGCGG
AACGCAGCCGCCGCCTCGGCTTGACCAATGAGGATGTCGAGGCCCTCGACCAGGCTCGTGACAAGGCGCCCGCCAAGCCG
ATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7HSF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3XGK1

References