Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1345022..1345695 Replicon chromosome
Accession NC_009719
Organism Parvibaculum lavamentivorans DS-1

Toxin (Protein)


Gene name vapC Uniprot ID A7HSF1
Locus tag PLAV_RS06175 Protein ID WP_012110102.1
Coordinates 1345022..1345444 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3XGK1
Locus tag PLAV_RS06180 Protein ID WP_012110103.1
Coordinates 1345441..1345695 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLAV_RS06140 1340858..1341139 - 282 WP_012110094.1 helix-turn-helix domain-containing protein -
PLAV_RS06145 1341276..1341905 - 630 WP_083762510.1 DUF2285 domain-containing protein -
PLAV_RS06150 1342168..1342428 - 261 WP_012110096.1 DUF2285 domain-containing protein -
PLAV_RS06155 1342525..1342791 - 267 WP_012110097.1 helix-turn-helix transcriptional regulator -
PLAV_RS06160 1343099..1343425 - 327 WP_041535876.1 DUF736 domain-containing protein -
PLAV_RS06170 1343998..1344438 - 441 WP_012110100.1 hypothetical protein -
PLAV_RS19615 1344573..1344740 - 168 WP_012110101.1 hypothetical protein -
PLAV_RS06175 1345022..1345444 - 423 WP_012110102.1 type II toxin-antitoxin system VapC family toxin Toxin
PLAV_RS06180 1345441..1345695 - 255 WP_012110103.1 plasmid stabilization protein Antitoxin
PLAV_RS06185 1345782..1346708 - 927 WP_012110104.1 DUF2493 domain-containing protein -
PLAV_RS06190 1347060..1348094 - 1035 WP_012110105.1 toprim domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1295685..1402390 106705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14928.09 Da        Isoelectric Point: 4.5093

>T22348 WP_012110102.1 NC_009719:c1345444-1345022 [Parvibaculum lavamentivorans DS-1]
MILLDTNVVSEAMKPAPDEAVRAWLDEQAAETLFLSSVTIAELMFGIGALPDGKRKERLTEALDGVMELFADRVLPFDVD
AARRYADLAVKARAAGKGFPTPDGYIAAIAAAKGFAVATRDSSAFEAANVTVIDPWKAGR

Download         Length: 423 bp

>T22348 NC_009719:c1345444-1345022 [Parvibaculum lavamentivorans DS-1]
ATGATCCTCCTCGACACCAATGTCGTATCGGAGGCGATGAAGCCCGCTCCCGACGAGGCCGTGCGCGCATGGCTCGACGA
GCAGGCGGCGGAAACACTCTTTCTCTCCAGCGTCACCATCGCCGAACTGATGTTCGGCATCGGCGCGCTCCCCGACGGCA
AGCGCAAGGAGCGTCTCACCGAAGCCCTGGATGGGGTGATGGAACTGTTCGCAGACCGCGTCCTCCCGTTCGATGTCGAT
GCTGCGCGCCGCTATGCGGATCTCGCCGTCAAAGCCCGAGCGGCCGGGAAAGGCTTCCCTACTCCCGACGGCTACATCGC
GGCGATTGCAGCCGCCAAGGGGTTTGCCGTCGCCACGCGCGACAGCAGCGCATTCGAGGCCGCGAATGTCACGGTGATCG
ATCCCTGGAAGGCCGGGCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9351.67 Da        Isoelectric Point: 10.4317

>AT22348 WP_012110103.1 NC_009719:c1345695-1345441 [Parvibaculum lavamentivorans DS-1]
MPAVTIRNLSDATHRALKVRAAQHGRSAEAEMRDILEMAVRPDTRLRLGTALAERSRRLGLTNEDVEALDQARDKAPAKP
MSFE

Download         Length: 255 bp

>AT22348 NC_009719:c1345695-1345441 [Parvibaculum lavamentivorans DS-1]
ATGCCCGCAGTTACGATCAGGAATCTGTCCGACGCGACGCATCGCGCCCTCAAGGTGCGGGCGGCGCAGCACGGCCGCAG
CGCCGAAGCGGAAATGCGCGACATCCTCGAAATGGCTGTCCGCCCCGATACGCGCCTCCGGCTCGGCACGGCGCTCGCGG
AACGCAGCCGCCGCCTCGGCTTGACCAATGAGGATGTCGAGGCCCTCGACCAGGCTCGTGACAAGGCGCCCGCCAAGCCG
ATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7HSF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3XGK1

References