Detailed information of TA system TA022346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 771505..772049
• Replicon: chromosome
• Accession: NC_009719
• Organism: Parvibaculum lavamentivorans DS-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A7HR01
• Locus tag: PLAV_RS03620
• Protein ID: WP_011995625.1
• Coordinates: 771747..772049 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: PLAV_RS03615
• Protein ID: WP_041535829.1
• Coordinates: 771505..771750 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PLAV_RS03585	766718..767548	-	831	WP_011995618.1	alpha/beta hydrolase	-
PLAV_RS03590	767794..768264	+	471	WP_011995619.1	MarR family transcriptional regulator	-
PLAV_RS03595	768342..768629	-	288	WP_041535828.1	GIY-YIG nuclease family protein	-
PLAV_RS03600	768698..769927	-	1230	WP_083762665.1	PA0069 family radical SAM protein	-
PLAV_RS03605	770106..770801	+	696	WP_041536300.1	TIGR04283 family arsenosugar biosynthesis glycosyltransferase	-
PLAV_RS03610	770807..771406	+	600	WP_011995623.1	TIGR04282 family arsenosugar biosynthesis glycosyltransferase	-
PLAV_RS03615	771505..771750	+	246	WP_041535829.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
PLAV_RS03620	771747..772049	+	303	WP_011995625.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PLAV_RS03625	772078..772506	-	429	WP_011995626.1	large conductance mechanosensitive channel protein MscL	-
PLAV_RS03630	772587..773126	-	540	WP_011995627.1	molybdenum cofactor biosynthesis protein B	-
PLAV_RS03635	773348..776557	-	3210	WP_011995628.1	multidrug efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11104.69 Da
• Isoelectric Point: 7.2759

>T22346 WP_011995625.1 NC_009719:771747-772049 [Parvibaculum lavamentivorans DS-1]
MSAYVFSPAARADLEEIWNYSVEQWGAERAETYILQIRDACEALAGGKKKGRAIDGIRPGYLKLAAGSHFLFFRIGNGGV
IDVVRILHQRMDVSAHLNEP

Nucleotide

• Length: 303 bp

>T22346 NC_009719:771747-772049 [Parvibaculum lavamentivorans DS-1]
ATGAGCGCCTATGTCTTTTCGCCAGCCGCGCGAGCCGATCTCGAAGAGATATGGAACTACTCCGTCGAGCAATGGGGCGC
GGAACGGGCTGAGACCTACATTCTGCAAATTCGCGATGCCTGCGAGGCGCTGGCGGGCGGGAAAAAGAAGGGCCGCGCGA
TCGACGGCATTCGCCCCGGCTATCTGAAGCTCGCCGCCGGTTCCCATTTTCTGTTCTTTCGTATCGGGAACGGCGGGGTC
ATCGACGTGGTGCGGATACTTCATCAGCGCATGGACGTATCCGCGCATCTGAACGAGCCGTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8954.95 Da
• Isoelectric Point: 6.4682

>AT22346 WP_041535829.1 NC_009719:771505-771750 [Parvibaculum lavamentivorans DS-1]
MAKNTSISLGDHFNDFVESRVARGRYGSASEVVRAALRLLEEHEAKVEALRAALIAGEQSGPSSPFDFDDFIREKQTSRS
K

Nucleotide

• Length: 246 bp

>AT22346 NC_009719:771505-771750 [Parvibaculum lavamentivorans DS-1]
ATGGCAAAGAATACGTCCATTTCCCTCGGGGATCATTTCAACGACTTTGTCGAAAGCCGGGTGGCGCGTGGCCGTTACGG
CTCGGCAAGCGAGGTCGTGCGTGCCGCCTTGCGGCTGCTCGAGGAGCATGAAGCGAAGGTGGAAGCGCTGCGCGCGGCCC
TGATCGCGGGCGAACAAAGCGGCCCGTCCTCGCCGTTCGATTTCGATGATTTTATCCGCGAGAAACAGACGTCGCGCTCG
AAATGA

Structures

Toxin

• AlphaFold DB: A7HR01