Detailed information of TA system TA022345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 236368..236918
• Replicon: chromosome
• Accession: NC_009719
• Organism: Parvibaculum lavamentivorans DS-1

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: PLAV_RS01115
• Protein ID: WP_041535785.1
• Coordinates: 236368..236685 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: PLAV_RS01120
• Protein ID: WP_202943992.1
• Coordinates: 236697..236918 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PLAV_RS19565	231625..231786	+	162	WP_168713160.1	hypothetical protein	-
PLAV_RS01085	231981..233228	+	1248	WP_011995124.1	LLM class flavin-dependent oxidoreductase	-
PLAV_RS01090	233374..233748	+	375	WP_083762656.1	MarR family transcriptional regulator	-
PLAV_RS01095	233775..234722	+	948	WP_011995126.1	phytanoyl-CoA dioxygenase family protein	-
PLAV_RS01100	234866..235216	+	351	WP_168713161.1	hypothetical protein	-
PLAV_RS19745	235266..235808	+	543	WP_011995128.1	hypothetical protein	-
PLAV_RS01110	235830..236357	-	528	WP_011995129.1	VOC family protein	-
PLAV_RS01115	236368..236685	-	318	WP_041535785.1	CcdB family protein	Toxin
PLAV_RS01120	236697..236918	-	222	WP_202943992.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
PLAV_RS01125	237153..237353	+	201	WP_011995132.1	50S ribosomal protein L35	-
PLAV_RS01130	237383..237739	+	357	WP_011995133.1	50S ribosomal protein L20	-
PLAV_RS01135	237954..239039	+	1086	WP_011995134.1	phenylalanine--tRNA ligase subunit alpha	-
PLAV_RS01140	239036..241474	+	2439	WP_011995135.1	phenylalanine--tRNA ligase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (3-104)

Antitoxin

• Post-segregation antitoxin CcdA (3-73)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11698.67 Da
• Isoelectric Point: 6.4662

>T22345 WP_041535785.1 NC_009719:c236685-236368 [Parvibaculum lavamentivorans DS-1]
MAQFDVYRNRNAASREAIPYFLLLQHEVIETRALRVVVPLVPLSRAELPISRLNPIFEIEGRKLILSTLEIAGISTSFLG
GDIVASLSHRRDEIIAAIDFLVTGI

Nucleotide

• Length: 318 bp

>T22345 NC_009719:c236685-236368 [Parvibaculum lavamentivorans DS-1]
ATGGCGCAATTCGATGTCTATCGGAACAGGAATGCCGCCAGCCGCGAGGCCATTCCATACTTCCTGCTTTTGCAACACGA
GGTGATCGAGACGCGGGCCCTGCGCGTCGTTGTCCCTCTCGTTCCGCTATCGCGGGCTGAACTGCCTATCAGCCGCCTGA
ACCCGATTTTCGAAATCGAGGGAAGAAAGCTCATTCTCTCGACGCTGGAAATCGCGGGCATATCGACATCGTTCCTCGGC
GGCGACATTGTGGCGTCGCTCTCTCACCGCAGGGACGAAATCATCGCCGCTATCGATTTTCTCGTGACGGGTATCTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8614.76 Da
• Isoelectric Point: 8.8297

>AT22345 WP_202943992.1 NC_009719:c236918-236697 [Parvibaculum lavamentivorans DS-1]
MPKKAVNLSIDADLLAKARALDINLSATFEEVLRTRAREEERKRWVEENRDAIEAFNRRIERDGVWSDGLRRF

Nucleotide

• Length: 222 bp

>AT22345 NC_009719:c236918-236697 [Parvibaculum lavamentivorans DS-1]
ATGCCAAAGAAAGCCGTCAATCTCAGCATCGATGCCGACCTCCTCGCCAAGGCGCGGGCGCTGGATATCAATCTTTCCGC
GACCTTCGAAGAAGTGCTGCGAACCCGCGCCCGCGAGGAAGAGCGCAAACGCTGGGTAGAGGAAAACCGGGACGCCATCG
AAGCTTTCAACCGCCGGATCGAGCGAGACGGTGTATGGAGCGACGGCCTTCGCCGTTTCTAG