Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1834064..1834684 Replicon chromosome
Accession NZ_CP086292
Organism Burkholderia ambifaria strain B21-008

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LL999_RS24215 Protein ID WP_229062544.1
Coordinates 1834064..1834381 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LL999_RS24220 Protein ID WP_006750245.1
Coordinates 1834385..1834684 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL999_RS24200 (LL999_24220) 1829439..1830872 - 1434 WP_229062541.1 aldehyde dehydrogenase family protein -
LL999_RS24205 (LL999_24225) 1830901..1832541 - 1641 WP_012365545.1 acetolactate synthase large subunit -
LL999_RS24210 (LL999_24230) 1832634..1833686 + 1053 WP_229062543.1 transposase -
LL999_RS24215 (LL999_24235) 1834064..1834381 + 318 WP_229062544.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LL999_RS24220 (LL999_24240) 1834385..1834684 + 300 WP_006750245.1 putative addiction module antidote protein Antitoxin
LL999_RS24225 (LL999_24245) 1834745..1836031 - 1287 WP_175705455.1 DUF445 domain-containing protein -
LL999_RS24230 (LL999_24250) 1836226..1837446 - 1221 WP_229062545.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
LL999_RS24235 (LL999_24255) 1837436..1837762 - 327 WP_006756593.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
LL999_RS24240 (LL999_24260) 1837779..1838267 - 489 WP_229062547.1 anthranilate 1,2-dioxygenase small subunit AndAd -
LL999_RS24245 (LL999_24265) 1838264..1839553 - 1290 WP_126226708.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-90)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11825.55 Da        Isoelectric Point: 9.9422

>T222926 WP_229062544.1 NZ_CP086292:1834064-1834381 [Burkholderia ambifaria]
MPYSAPTFSIRTTDVFDAWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRGTIWVILL
CGGDKSTQQGDIRAAHAMLARLDLE

Download         Length: 318 bp

>T222926 NZ_CP118156:424376-424657 [Pseudomonas chlororaphis]
ATGACTTATAAACTCCAGTTTCTGCCTTCGGCGCGCAAGGAATGGGACAAGCTCGGTCATACCCTGCGCGAGCAATTCAA
GAAGAAGCTGGCCGAGCGCCTGGAAATGCCACGGGTGCCCGCGGATGCCCTTCACGGCATGGCGGACTGCTACAAGATCA
AGCTCAAGGCCTCTGGCTATCGCCTGGTTTACCAAGTGATCGAGGATCAGGTGGTGGTTTCGGTGGTGGCCGTGGGCAAA
CGTGAACGCAGCGCCGTGTATGAGCGGGCACGAAAGCGCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10674.11 Da        Isoelectric Point: 6.6384

>AT222926 WP_006750245.1 NZ_CP086292:1834385-1834684 [Burkholderia ambifaria]
MDKIKTRPWDSAEHLKTDDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT222926 NZ_CP118156:424141-424386 [Pseudomonas chlororaphis]
ATGCAAAGCGTATTGGCTGATAAAGCTGTCAGCGTGTCTGAACTGAAAAAAAACCCCTCGGCTGTCCTGAGCGGCGCACA
CGGTGGTCCGGTTGCGGTGCTCAATCACAACCGGGTCATGGGCTATATGGTCCCGGCCGACGTGTTTGAAGCCATGATGG
AGCGTCTTGACGATCTTGAACTGGCGGAGATTGTCCGTGCCCGTCGGCACGAGACCCCAGTCCCGGTAAATCTGGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References