Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2833332..2833848 Replicon chromosome
Accession NZ_CP086213
Organism Pseudomonas aeruginosa strain Pa3

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag LLJ53_RS13735 Protein ID WP_025297453.1
Coordinates 2833567..2833848 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag LLJ53_RS13730 Protein ID WP_025297454.1
Coordinates 2833332..2833577 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLJ53_RS13710 (LLJ53_13725) 2828454..2828783 - 330 WP_031692728.1 hypothetical protein -
LLJ53_RS13715 (LLJ53_13730) 2829131..2829799 + 669 WP_071534660.1 hypothetical protein -
LLJ53_RS13720 (LLJ53_13735) 2829796..2830902 + 1107 WP_025297456.1 XRE family transcriptional regulator -
LLJ53_RS13725 (LLJ53_13740) 2831033..2833174 + 2142 WP_025297455.1 hypothetical protein -
LLJ53_RS13730 (LLJ53_13745) 2833332..2833577 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LLJ53_RS13735 (LLJ53_13750) 2833567..2833848 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LLJ53_RS13740 (LLJ53_13755) 2834254..2834835 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
LLJ53_RS13745 (LLJ53_13760) 2834849..2835724 - 876 WP_033895413.1 WYL domain-containing protein -
LLJ53_RS13750 (LLJ53_13765) 2835853..2837433 + 1581 WP_063837559.1 DNA recombination protein RmuC -
LLJ53_RS13755 (LLJ53_13770) 2837457..2837849 + 393 WP_227274803.1 hypothetical protein -
LLJ53_RS13760 (LLJ53_13775) 2837833..2838105 + 273 WP_227274804.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2816567..2884291 67724


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T222754 WP_025297453.1 NZ_CP086213:2833567-2833848 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

>T222754 NZ_CP118135:c1293134-1292856 [Pseudomonas chlororaphis]
GTGAGGGAATTGAAATGGACGAGCAAGGCACTGTCGGATCTGGCCCGACTGTTTGAGTTTCTTGCTCCGGTGAACCGTTC
GGTGGCAGCTCGAACTGTGCAATCGCTCACGCAGGCCCCGGATACCCTGCTGACCAATCCGCGTATCGGCGAACAGTTGG
AGGAGTTTCAGCCTCGCGATGTTCGGCGTTTATTGGTCGGGCCTTACGAGATGCGTTACGAGATCCAGGATGCGACGCTC
TACATCCTGCGGGTGTGGCATGTACGAGAAGACCGCTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT222754 WP_025297454.1 NZ_CP086213:2833332-2833577 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp

>AT222754 NZ_CP118135:c1293394-1293131 [Pseudomonas chlororaphis]
ATGACCGCAACTAAAGTGCTGACCGCACATGTGCCGTTGGAGTTGGCCGACAAGGTCGACCAGATGGCCTCCCGGCTGGA
GCGCTCGCGCGGCTGGATCGTCAAGCAGGCTCTGGTGGCGTGGGTCGATCAGGAAGAGGAGCGCAGTCGCCTGACCCATG
AGGCTTTGGCCGATGTGGATGCTGGGCGGGTCATCGATCACCAGGCTGTCCAGGCATGGGCCGAGAGCCTGATGAATGAC
AAGCCTTTGCCGGTGCCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References