Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2535013..2535530 | Replicon | chromosome |
| Accession | NC_009641 | ||
| Organism | Staphylococcus aureus subsp. aureus str. Newman | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | NWMN_RS13260 | Protein ID | WP_000113262.1 |
| Coordinates | 2535013..2535279 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | NWMN_RS13265 | Protein ID | WP_000584499.1 |
| Coordinates | 2535279..2535530 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NWMN_RS13235 (NWMN_2302) | 2530440..2530976 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| NWMN_RS13240 (NWMN_2303) | 2531209..2532033 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| NWMN_RS13245 (NWMN_2304) | 2532250..2532432 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| NWMN_RS13250 (NWMN_2305) | 2532516..2532983 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| NWMN_RS13255 (NWMN_2306) | 2533123..2534718 | - | 1596 | WP_000727761.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| NWMN_RS15790 | 2534907..2534978 | - | 72 | Protein_2513 | hypothetical protein | - |
| NWMN_RS13260 (NWMN_2307) | 2535013..2535279 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| NWMN_RS13265 | 2535279..2535530 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| NWMN_RS13270 | 2535695..2535796 | - | 102 | WP_001791744.1 | hypothetical protein | - |
| NWMN_RS13275 (NWMN_2308) | 2535803..2536402 | - | 600 | WP_000162813.1 | DsbA family protein | - |
| NWMN_RS13280 (NWMN_2309) | 2536421..2536783 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| NWMN_RS13285 (NWMN_2310) | 2537038..2538288 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| NWMN_RS13290 (NWMN_2311) | 2538385..2539116 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| NWMN_RS13295 (NWMN_2312) | 2539113..2539832 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T22275 WP_000113262.1 NC_009641:c2535279-2535013 [Staphylococcus aureus subsp. aureus str. Newman]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T22275 NC_009641:c2535279-2535013 [Staphylococcus aureus subsp. aureus str. Newman]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT22275 WP_000584499.1 NC_009641:c2535530-2535279 [Staphylococcus aureus subsp. aureus str. Newman]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT22275 NC_009641:c2535530-2535279 [Staphylococcus aureus subsp. aureus str. Newman]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|