Detailed information of TA system TA222607

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 3567978..3568378
• Replicon: chromosome
• Accession: NZ_CP086133
• Organism: Pantoea agglomerans strain DBM 3797

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: LKW31_RS16760
• Protein ID: WP_033787451.1
• Coordinates: 3567978..3568307 (-)
• Length: 110 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	3568302..3568378 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LKW31_RS16740 (3564987)	3564987..3565679	+	693	WP_022625337.1	LuxR family transcriptional regulator	-
LKW31_RS16745 (3565694)	3565694..3566332	-	639	WP_031593697.1	acyl-homoserine-lactone synthase	-
LKW31_RS16750 (3567483)	3567483..3567746	-	264	WP_228312302.1	hypothetical protein	-
LKW31_RS16755 (3567715)	3567715..3567936	-	222	WP_228312673.1	DUF2778 domain-containing protein	-
LKW31_RS16760 (3567978)	3567978..3568307	-	330	WP_033787451.1	endoribonuclease SymE	Toxin
- (3568302)	3568302..3568378	+	77	NuclAT_0	-	Antitoxin
- (3568302)	3568302..3568378	+	77	NuclAT_0	-	Antitoxin
- (3568302)	3568302..3568378	+	77	NuclAT_0	-	Antitoxin
- (3568302)	3568302..3568378	+	77	NuclAT_0	-	Antitoxin
- (3568302)	3568302..3568378	+	77	NuclAT_1	-	Antitoxin
- (3568302)	3568302..3568378	+	77	NuclAT_1	-	Antitoxin
- (3568302)	3568302..3568378	+	77	NuclAT_1	-	Antitoxin
- (3568302)	3568302..3568378	+	77	NuclAT_1	-	Antitoxin
LKW31_RS16765 (3568830)	3568830..3569153	-	324	WP_039386786.1	DNA-binding transcriptional regulator	-
LKW31_RS16770 (3569137)	3569137..3569381	-	245	Protein_3272	type II toxin-antitoxin system RelE/ParE family toxin	-
LKW31_RS16775 (3569585)	3569585..3570637	+	1053	WP_228312303.1	hypothetical protein	-
LKW31_RS16780 (3570631)	3570631..3570906	+	276	WP_033759756.1	hypothetical protein	-
LKW31_RS16785 (3571091)	3571091..3571288	+	198	Protein_3275	MarR family transcriptional regulator	-
LKW31_RS16790 (3571296)	3571296..3572105	+	810	Protein_3276	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3561870..3590067	28197
	-	flank	IS/Tn	-	-	3571332..3572105	773

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12056.93 Da
• Isoelectric Point: 9.0982

>T222607 WP_033787451.1 NZ_CP086133:c3568307-3567978 [Pantoea agglomerans]
MTDAHSIAQLSEPEVSPADNRKLTVSYASRYPDYSRIPAITMKGQWLEAAGFATGTAVDVKVMEGCIVLTARQESELMQS
LRQVCKLSARKQKQVQEFIQVIAGKQKVV

Nucleotide

• Length: 330 bp

>T222607 NZ_CP117971:c2748967-2748791 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGTGTCACCCTAGCGATGAGATTAAAGAACCATTGCGTAAAGCAATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT222607 NZ_CP086133:3568302-3568378 [Pantoea agglomerans]
AGTCATGATTACTATTCTCCGTAAATAGTAGTTGTGATTAGCGGCGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin