Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 791805..792462 Replicon chromosome
Accession NZ_CP086128
Organism Klebsiella pneumoniae strain MIN-109

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LLZ91_RS03895 Protein ID WP_002916310.1
Coordinates 792052..792462 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LLZ91_RS03890 Protein ID WP_002916312.1
Coordinates 791805..792071 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLZ91_RS03865 (LLZ91_03870) 786961..788394 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LLZ91_RS03870 (LLZ91_03875) 788513..789241 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LLZ91_RS03875 (LLZ91_03880) 789291..789602 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LLZ91_RS03880 (LLZ91_03885) 789766..790425 + 660 WP_002916317.1 hemolysin III family protein -
LLZ91_RS03885 (LLZ91_03890) 790576..791559 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LLZ91_RS03890 (LLZ91_03895) 791805..792071 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LLZ91_RS03895 (LLZ91_03900) 792052..792462 + 411 WP_002916310.1 protein YgfX Toxin
LLZ91_RS03900 (LLZ91_03905) 792469..792990 - 522 WP_004144730.1 flavodoxin FldB -
LLZ91_RS03905 (LLZ91_03910) 793091..793987 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LLZ91_RS03910 (LLZ91_03915) 794010..794723 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LLZ91_RS03915 (LLZ91_03920) 794729..796462 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T222583 WP_002916310.1 NZ_CP086128:792052-792462 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T222583 NZ_CP117967:246157-247017 [Veillonella rogosae]
ATGGTAAAACTTGAAAATACTATTAAAGAGTCATTAACACAAGCTTCTCATGACATTAGTGATGTTAAAGCTGTTAAAGA
GACTAGTGATGTACAAGCTATTGAGTCCTATAGTTCTGAAGACTTTGAAAAGGCCTTAGAACGTACCATTGATTTCTTAA
CGTTTAATAAAAATATATCTAGTACACCTCGTGCTGTTATTTTAGGTGGTCAAAGTGGAGCAGGGAAAACCACAATTCAT
CGTGTGAAAATGCTAGAGTCAAAAGGTAATTATATTGTCATTGATGGCGATACATATCGTGCTCAACATCCGTATTTTAG
AGAGTTACAAGAGAAATATGGTGTTGATAGTGTAGATTACACAAAAATGTTTGCAGGTAAGATGGTAGAGGCTGTAATTG
ATAAATTAAGCTCTTTAAAATACAATTTGATTATTGAAGGCACATTACGTTCAGCCGCAGTACCAATTAATACAGCTACA
TTATTAAAATCTAAAGGCTATACCGTCGACTTTTGTTTGATTGCTACTAAGCCAGAGTTATCTTATTTGACGACGCAATT
GCGCTATTTAGAAATGATGAGCGTGGATCCTTTACAAGCGAGAGCGACACCTAAAGAGCATCATGATGGAATTGTAAAGT
CTTTGGTCGCTAATATTACTGAACTTGAACAGAGTGGACTTTTTGAAAGCCTTCTAGTGTATAAACGTAATTTAGAACAA
GTATATAATTCAAAATTATGTACTGAATCTGTTGGAACTGTTGTAGAACAAATTTTATTTGGTCCGTGGACTAAAGATGA
ATCTACCTTGTTAGAAGTGAGTAAATCACAGGAACAGGCATTAAGAGCGAAATTGCCTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT222583 WP_002916312.1 NZ_CP086128:791805-792071 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT222583 NZ_CP117967:245950-246072 [Veillonella rogosae]
ATGAATGTCGTTGAACAGTATAATTTAACTTTACAAATAGAAGTTCTAAAAGAACAAAGTGCGGAAACATTAGCGCGTCT
CTGTAACTTAGTTGAGGAGAGTGGCACTAGTGACTGTATATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References