Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 5719..6740 Replicon plasmid pSM-2
Accession NZ_CP086108
Organism Skermanella mucosa strain KEMB 2255-438

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag JL100_RS33030 Protein ID WP_228421747.1
Coordinates 5719..6291 (-) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag JL100_RS33035 Protein ID WP_202683336.1
Coordinates 6291..6740 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL100_RS33020 (JL100_033110) 1766..4540 + 2775 WP_202683334.1 formate dehydrogenase subunit alpha -
JL100_RS33025 (JL100_033115) 4884..5711 + 828 WP_228421718.1 IclR family transcriptional regulator C-terminal domain-containing protein -
JL100_RS33030 (JL100_033120) 5719..6291 - 573 WP_228421747.1 PIN domain-containing protein Toxin
JL100_RS33035 (JL100_033125) 6291..6740 - 450 WP_202683336.1 helix-turn-helix domain-containing protein Antitoxin
JL100_RS33040 (JL100_033130) 7044..7346 - 303 WP_202683337.1 helix-turn-helix transcriptional regulator -
JL100_RS33045 (JL100_033135) 7385..7843 - 459 WP_202683338.1 type II toxin-antitoxin system VapC family toxin -
JL100_RS33050 (JL100_033140) 7891..8133 - 243 WP_202683339.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JL100_RS33055 (JL100_033145) 8725..10074 + 1350 WP_228421149.1 IS1380 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..434629 434629
- flank IS/Tn - - 8725..10074 1349


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-114)

Antitoxin

SinI-like, DNA-binding domain

(79-126)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21351.54 Da        Isoelectric Point: 6.2923

>T222530 WP_228421747.1 NZ_CP086108:c6291-5719 [Skermanella mucosa]
ILAGFTVVYDACVLYPAPLRDLLIELAAANLFRAKWTDAIHDEWIRNLLSNRPDLGIERLRRTRELMNTAVLDCLVKGYE
HLTPAVSLPDEDDRHVVAAAIHSRADAIVTFNLKDFPASELSRHDLEAVHPDEFIQHLFELDGAAVVIAAQRCHRKLKNP
PKSAGEYLDTLLRQSLPKTVASLRPFSEVI

Download         Length: 573 bp

>T222530 NZ_CP117959:4689258-4689545 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16689.03 Da        Isoelectric Point: 5.6560

>AT222530 WP_202683336.1 NZ_CP086108:c6740-6291 [Skermanella mucosa]
MNALIRRPESVVPTDEDTRLAAELSRVLAANGENAALRVQLDDGRALTLPMAATRLLEQVLTEMAHGNAVTLIPVHAELT
TQEAADYLNVSRPYLVRLLEENFIPFHKVGTHRRVRFQDLKTFKEQADAKRRDAMGELVAQAQELDLGY

Download         Length: 450 bp

>AT222530 NZ_CP117959:4689532-4689834 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References