Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 494402..495012 Replicon plasmid megaplasmid
Accession NZ_CP086105
Organism Ralstonia sp. RS650

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LGV82_RS20120 Protein ID WP_247394605.1
Coordinates 494402..494710 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LGV82_RS20125 Protein ID WP_016722339.1
Coordinates 494707..495012 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGV82_RS20095 (LGV82_20090) 490721..491320 - 600 WP_071013505.1 GNAT family N-acetyltransferase -
LGV82_RS20100 (LGV82_20095) 491452..492003 + 552 WP_071013501.1 helix-turn-helix domain-containing protein -
LGV82_RS20105 (LGV82_20100) 492181..493002 + 822 WP_011003398.1 GntR family transcriptional regulator -
LGV82_RS20110 (LGV82_20105) 493129..493425 + 297 Protein_383 MFS transporter -
LGV82_RS20115 (LGV82_20110) 493565..494326 + 762 WP_265069647.1 hypothetical protein -
LGV82_RS20120 (LGV82_20115) 494402..494710 + 309 WP_247394605.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGV82_RS20125 (LGV82_20120) 494707..495012 + 306 WP_016722339.1 putative addiction module antidote protein Antitoxin
LGV82_RS20130 (LGV82_20125) 495225..496538 + 1314 WP_247394606.1 MFS family transporter -
LGV82_RS20135 (LGV82_20130) 496643..497311 - 669 WP_038938024.1 hypothetical protein -
LGV82_RS20140 (LGV82_20135) 497370..498620 + 1251 WP_103025565.1 IS256 family transposase -
LGV82_RS20145 (LGV82_20140) 498829..498980 - 152 Protein_390 IS5/IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fliI / fliG / fliM / flgG / flgC / cyaB / motA / cheW / cheB / cheY / adeG / acrB 1..2073962 2073962


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-88)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-96)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11836.59 Da        Isoelectric Point: 6.7121

>T222522 WP_247394605.1 NZ_CP086105:494402-494710 [Ralstonia sp. RS650]
MLTIHTTEIFDDWFCSLRDKAAQRRIQVRIDRLQMGNPGDMKALRDGIRELRIDHGPGDRLYFVRHGVVLIVLLCGGDKS
TQETDIRRAIDLSRRLDVDDME

Download         Length: 309 bp

>T222522 NZ_CP117959:c2930169-2929762 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10967.57 Da        Isoelectric Point: 7.2780

>AT222522 WP_016722339.1 NZ_CP086105:494707-495012 [Ralstonia sp. RS650]
MTMAQRTIKTRPWDSAEHLRTEADIAAYLDACLEEAGDDPAFITHALGVVARSRGMTQLARETGMTREGLYKALSEGGNP
SFATVLKVIRALGIRLHAVPT

Download         Length: 306 bp

>AT222522 NZ_CP117959:c2930416-2930150 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References