Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 2825528..2826189 Replicon chromosome
Accession NZ_CP086104
Organism Ralstonia sp. RS650

Toxin (Protein)


Gene name vapC Uniprot ID A0A9E7Z845
Locus tag LGV82_RS13140 Protein ID WP_016727753.1
Coordinates 2825776..2826189 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7Z6P3
Locus tag LGV82_RS13135 Protein ID WP_019717749.1
Coordinates 2825528..2825779 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGV82_RS13115 (LGV82_13095) 2821177..2821893 + 717 WP_049800424.1 Crp/Fnr family transcriptional regulator -
LGV82_RS13120 (LGV82_13105) 2823180..2823395 + 216 WP_071615547.1 hypothetical protein -
LGV82_RS13125 (LGV82_13110) 2823549..2824094 - 546 WP_231676102.1 DUF6441 family protein -
LGV82_RS13130 (LGV82_13115) 2824699..2825253 + 555 WP_019717750.1 XopAF/AvrXv3 family type III secretion system effector -
LGV82_RS13135 (LGV82_13120) 2825528..2825779 + 252 WP_019717749.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LGV82_RS13140 (LGV82_13125) 2825776..2826189 + 414 WP_016727753.1 type II toxin-antitoxin system VapC family toxin Toxin
LGV82_RS13145 (LGV82_13130) 2826261..2827283 - 1023 WP_020425162.1 DNA cytosine methyltransferase -
LGV82_RS13150 (LGV82_13135) 2827898..2828185 + 288 WP_089190399.1 H-NS family nucleoid-associated regulatory protein -
LGV82_RS13155 (LGV82_13140) 2828228..2828872 - 645 WP_089190400.1 DUF6441 family protein -
LGV82_RS13160 (LGV82_13145) 2828847..2829002 - 156 WP_016727777.1 hypothetical protein -
LGV82_RS13165 (LGV82_13150) 2829065..2829454 - 390 WP_089190402.1 hypothetical protein -
LGV82_RS13170 (LGV82_13155) 2829615..2829824 + 210 WP_265069452.1 UDP-glycosyltransferase family protein -
LGV82_RS13175 (LGV82_13160) 2829821..2830861 + 1041 WP_265069453.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15586.89 Da        Isoelectric Point: 6.2337

>T222520 WP_016727753.1 NZ_CP086104:2825776-2826189 [Ralstonia sp. RS650]
MSYLIDTNVLSELRRKAPDARVVAWMQDRPRQSLYLSVLTLGEIRKGIERLDDAARRQHLIDWLEVELPNYFLGRLLDID
AHTADRWGRLMSSAGRPLPAIDGLLAATALQHDLTLVTRNTKDFAGLDVQLINPWEA

Download         Length: 414 bp

>T222520 NZ_CP117959:c2012872-2012621 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9305.49 Da        Isoelectric Point: 5.0774

>AT222520 WP_019717749.1 NZ_CP086104:2825528-2825779 [Ralstonia sp. RS650]
MQSWQMQAAKARFSDVVKRAADDGPQEITVHGRPVAVVISRALFDRLSGGGESLVSFMRQSPLADQDDVVFERERSLPRE
VEF

Download         Length: 252 bp

>AT222520 NZ_CP117959:c2012624-2012370 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References