Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 161020..161614 Replicon chromosome
Accession NZ_CP085972
Organism Bordetella parapertussis strain FDAARGOS_1540

Toxin (Protein)


Gene name hicA Uniprot ID K0M8J0
Locus tag LK435_RS00840 Protein ID WP_010928352.1
Coordinates 161020..161202 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID K0MFV7
Locus tag LK435_RS00845 Protein ID WP_010928351.1
Coordinates 161225..161614 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK435_RS00820 (LK435_00820) 156023..156763 + 741 WP_003809659.1 carbonic anhydrase -
LK435_RS00825 (LK435_00825) 156775..158130 - 1356 WP_003809657.1 cytochrome c -
LK435_RS00830 (LK435_00830) 158141..159910 - 1770 WP_010928353.1 GMC family oxidoreductase -
LK435_RS00835 (LK435_00835) 159914..160576 - 663 WP_226376529.1 gluconate 2-dehydrogenase subunit 3 family protein -
LK435_RS00840 (LK435_00840) 161020..161202 + 183 WP_010928352.1 type II toxin-antitoxin system HicA family toxin Toxin
LK435_RS00845 (LK435_00845) 161225..161614 + 390 WP_010928351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LK435_RS00855 (LK435_00855) 161880..162656 - 777 WP_033448479.1 phosphate ABC transporter ATP-binding protein PstB -
LK435_RS00860 (LK435_00860) 162701..163558 - 858 WP_003809638.1 phosphate ABC transporter permease PstA -
LK435_RS00865 (LK435_00865) 163580..164596 - 1017 WP_010928350.1 phosphate ABC transporter permease subunit PstC -
LK435_RS00870 (LK435_00870) 164731..165771 - 1041 WP_003809635.1 phosphate ABC transporter substrate-binding protein PstS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6750.76 Da        Isoelectric Point: 11.4018

>T222339 WP_010928352.1 NZ_CP085972:161020-161202 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Download         Length: 183 bp

>T222339 NZ_CP117820:c742561-742268 [Xylella fastidiosa]
ATGACCGAGAAACTGACGAGCTACGATCCAGCCGAGGACTTGACCACTGACCAGGCCATCGCCGATTTCATGGCAGCTGC
GTTCGGGACGAACGATCCTGCCTACGTTGCCCACGCGCTGGGCGTCGTTGCCCGCGCCAAGGGCATGACGCAGATCGCCA
GCCAGACAGGGCTATCGCGCGAACAGCTCTACCGCTCGTTCAGTGCCGAGGGCAACCCGACGCTGCGCACAACATTGGCC
GTGATGAAGGCGCTCGGGATCGAGCTGTCTGCGAAACCGTCTGGTGTTCACTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14270.92 Da        Isoelectric Point: 4.3014

>AT222339 WP_010928351.1 NZ_CP085972:161225-161614 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Download         Length: 390 bp

>AT222339 NZ_CP117820:c742860-742564 [Xylella fastidiosa]
ATGATTGAATTGAAGCAGACTGACACCTTCCGCAAGTGGCGGGAGAAACTCAAGGATGCGCGCGCCCGCTCGGCCATCGC
CTCGCGCCTCGACCGCTTGGCGTTCGGCCATGTCGGCGACGCCGAGCCAGTAGGGAAAGGTGTCAGCGAGCTTCGCATCA
ACTACGGCCCCGGTTACCGGGTGTATTTCCAGCGGCGTGGCGACACGATCTACTTGCTGCTTTGCGGCGGTGACAAAGGA
TCACAAGCGCGCGACATCAAGACTGCGCTGCACCTGTCTGAACAATGGAGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0M8J0

Antitoxin

Source ID Structure
AlphaFold DB K0MFV7

References