Detailed information of TA system TA222337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2476794..2477407
• Replicon: chromosome
• Accession: NZ_CP085971
• Organism: Bordetella parapertussis strain FDAARGOS_1541

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0MEM3
• Locus tag: LK409_RS11830
• Protein ID: WP_003811545.1
• Coordinates: 2476794..2477105 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LK409_RS11835
• Protein ID: WP_003811547.1
• Coordinates: 2477108..2477407 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK409_RS11805 (LK409_11805)	2471859..2472500	-	642	WP_010928709.1	LamB/YcsF family protein	-
LK409_RS11810 (LK409_11810)	2472497..2473891	-	1395	WP_003811536.1	arylsulfatase	-
LK409_RS11815 (LK409_11815)	2473906..2474868	-	963	WP_041937418.1	tripartite tricarboxylate transporter substrate binding protein	-
LK409_RS11820 (LK409_11820)	2474985..2475938	+	954	WP_041937234.1	LysR family transcriptional regulator	-
LK409_RS11825 (LK409_11825)	2476057..2476680	+	624	WP_003811542.1	glutathione S-transferase N-terminal domain-containing protein	-
LK409_RS11830 (LK409_11830)	2476794..2477105	+	312	WP_003811545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LK409_RS11835 (LK409_11835)	2477108..2477407	+	300	WP_003811547.1	NadS family protein	Antitoxin
LK409_RS11840 (LK409_11840)	2477421..2480013	-	2593	Protein_2335	autotransporter domain-containing protein	-
LK409_RS11845 (LK409_11845)	2480143..2480817	+	675	WP_010928712.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-96)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11810.72 Da
• Isoelectric Point: 8.8245

>T222337 WP_003811545.1 NZ_CP085971:2476794-2477105 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Nucleotide

• Length: 312 bp

>T222337 NZ_CP117820:c478157-477903 [Xylella fastidiosa]
ATGAAGCGTAAGCACGCTAAAACTCTCAGCGCTATATACACACGCCCTGTTTCGGCCAACATTCAATGGCGCGATATTGA
AGCGCTGTTCGTGGAGCTTGGAGCGAAAGTAGAAGAACGTGAAGGTTCTCGTATGTTGGTGCGGCTGTTCGGTGAACGTC
GGATATTCCACCGGCCCCACCCTTCGCCTAACACTGACAAGGGTGCTGTTGAATCAATCCGAGCTTGGTTGAAATCGAAC
GGAGTTACACCATGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10946.70 Da
• Isoelectric Point: 11.2467

>AT222337 WP_003811547.1 NZ_CP085971:2477108-2477407 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Nucleotide

• Length: 300 bp

>AT222337 NZ_CP117820:c477906-477571 [Xylella fastidiosa]
ATGAAGAACATCATGACTATTGAGAGCTTTAAAGCCATCATTACCTATGATCCGGAGATCGACATGTTTCGCGGTGAATT
TGTGGGTATCAATGGTGGTGCTGATTTCTATGCAAAAGACCTTAAGGGTCTTCGTCGAGAAGGAGCTATTTCTCTGAAGG
TATTTTTGGAAGCCTGCAAAGAAGACAGCGTGGAACCACGTAAATGCTACTCAGGGAAGTTCAATGCAAGGATTTCTCCT
GAACTGCATGCTTTGGCTTCTGAAGCCGCAGCAGCACAGGGCATCAGTTTGAACCAATTTGTAGAACAAGCGATTCAGCA
TGAAGTCCACACCTGA

Structures

Toxin

• AlphaFold DB: K0MEM3