Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1035692..1036323 Replicon chromosome
Accession NZ_CP085952
Organism Haemophilus influenzae strain FDAARGOS_1560

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag LK401_RS05325 Protein ID WP_005651560.1
Coordinates 1035692..1036090 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag LK401_RS05330 Protein ID WP_005648011.1
Coordinates 1036090..1036323 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK401_RS05305 (LK401_05305) 1030875..1031993 + 1119 WP_011272304.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
LK401_RS05310 (LK401_05310) 1031994..1033016 + 1023 WP_005693292.1 outer membrane-stress sensor serine endopeptidase DegS -
LK401_RS05315 (LK401_05315) 1033090..1033905 - 816 WP_011272305.1 DNA-formamidopyrimidine glycosylase -
LK401_RS05320 (LK401_05320) 1034137..1035672 - 1536 WP_011272306.1 L-2,4-diaminobutyrate decarboxylase -
LK401_RS05325 (LK401_05325) 1035692..1036090 - 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
LK401_RS05330 (LK401_05330) 1036090..1036323 - 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
LK401_RS05335 (LK401_05335) 1036470..1037834 - 1365 WP_005651563.1 diaminobutyrate--2-oxoglutarate transaminase -
LK401_RS05340 (LK401_05340) 1038181..1038351 - 171 WP_005613503.1 50S ribosomal protein L33 -
LK401_RS05345 (LK401_05345) 1038363..1038599 - 237 WP_005542826.1 50S ribosomal protein L28 -
LK401_RS05350 (LK401_05350) 1038813..1039478 - 666 WP_013526173.1 DNA repair protein RadC -
LK401_RS05355 (LK401_05355) 1039641..1040843 + 1203 WP_011272308.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T222309 WP_005651560.1 NZ_CP085952:c1036090-1035692 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T222309 NZ_CP117781:c743240-742650 [Burkholderia sp. FERM BP-3421]
ATGGACCTCGACACCCTCAAGGGACGCCTCGCCTTCCTGCGCGAGGCGGAACGACTCAAGGACGTACTCCGCAGCGGCCA
CACCTCGTCCGGCCGCCCCGAAAGCACGGCCGAGCACAGCTGGCGTCTGTGCCTGATGGCGCTCGTGTTCAGCGACGCGC
TCGACGGCGTCGATCCGCTGCGGATGCTCGGCATGTGCGTCGTGCACGATCTGGGCGAGGCGATCCACGGCGACATCCCC
GCGACGGAGCAGCATGCGCATCCGGACAAAAGCGCGCGCGAGCGGCAGGACCTGCTGCATCTGAGCCGCGCGCTCGACGA
CGGCATGCGCGCGCGTCTCCTCGCGCTCTGGGATGACTACGAGCGCGCGGCCAGCCCCGAAGCGCGCGCGGTCAAGGCGT
TCGACAAGCTGGAAACGATCCTGCAGCACGCGCAGGGCAAGAATCCCGACGATTTCGACTACGCGTTCAACCTCGCCTAC
GGGCGTCGGTACACGAGCGCCGCGCCCTTGTTCGAGGCGCTGCGCGCGCTCGTCGACGCCGACACGCAGGCGCGCATCGA
TACCCGGCCGGACGCGCAGGCCGAGGCATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT222309 WP_005648011.1 NZ_CP085952:c1036323-1036090 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT222309 NZ_CP117781:c743889-743284 [Burkholderia sp. FERM BP-3421]
ATGCACGACACCCGCCTCCACCCCGTTCCGATCGGCGCCGCCTTCAAGCGCTGGCGTCGGCTGCATCGGATCAAGCAGGC
GCACGCGGCCGCGCTGTTCGGCGTCGCGCAATCGACCATCTCGCGCTGGGAAAGCGGCCTTCACGACATGGAGCCCGCCG
AGCGCGCGCGCGTCGAACACGTGTTGTCCGCCCGGCTCGACGCCCCCGCCGATCACGCGCTCGCGCGCCTCGTCCGGGAG
AGCCCGCGCCCGGTCCACCTCGTCTGCGATCTCACGCATCGCCTGCTCGCGTGTTCGCCCACGCGCGCGGCCGAGTTCGG
CGCGCCGCTCGCCGATCTGCTCGGCCGCTCGCTGTGGCGCTACGCCACGCCCGAGATCATGGGCCAGGAAGCCGCGCTCG
ATACGCTGGGATGGCGCGACAGCCTCGCGCCGCCGGCGCTGGAATTCGCGACGGGCGTGAACGGCTCGGCGATCGTGCCG
ATCCATGCGGGCCGTTGCCGCTGGACCCGCATGACGCTCGCCGACGGTACCTCGGCCCGCCTCGTCGAGACGCTGCGGCC
GGCCGCGCATATTTCATGCGTGGACGCCGCGCGCGGCATTCCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References