Detailed information of TA system TA222029

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1278295..1278520
• Replicon: chromosome
• Accession: NZ_CP085822
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Charmeleon

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF58_RS06320
• Protein ID: WP_000813254.1
• Coordinates: 1278295..1278450 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1278462..1278520 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF58_RS06285	1273402..1273683	-	282	WP_000445513.1	phage holin family protein	-
LJF58_RS06290	1273673..1273861	-	189	WP_001688615.1	putative holin	-
LJF58_RS06295	1273855..1274178	-	324	Protein_1235	tellurite/colicin resistance protein	-
LJF58_RS06300	1276349..1276885	-	537	WP_000640113.1	DUF1133 family protein	-
LJF58_RS06305	1276882..1277172	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF58_RS06310	1277172..1277771	-	600	WP_000940751.1	DUF1367 family protein	-
LJF58_RS06315	1277834..1278004	-	171	WP_000734094.1	hypothetical protein	-
LJF58_RS06320	1278295..1278450	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	1278462..1278520	+	59	-	-	Antitoxin
LJF58_RS06325	1278877..1279809	+	933	WP_000556390.1	hypothetical protein	-
LJF58_RS06330	1279806..1280360	+	555	WP_001033796.1	hypothetical protein	-
LJF58_RS06335	1280522..1280851	-	330	WP_001676916.1	DUF977 family protein	-
LJF58_RS23000	1280895..1280942	-	48	Protein_1244	hypothetical protein	-
LJF58_RS06345	1281124..1281591	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF58_RS06350	1281976..1282131	+	156	WP_085981757.1	DUF1391 family protein	-
LJF58_RS06355	1282239..1282760	-	522	WP_000004762.1	super-infection exclusion protein B	-
LJF58_RS06360	1283198..1283419	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1272860..1284731	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T222029 WP_000813254.1 NZ_CP085822:c1278450-1278295 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T222029 NZ_CP117659:c2530792-2530637 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT222029 NZ_CP085822:1278462-1278520 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin