Detailed information of TA system TA222019

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1888972..1889197
• Replicon: chromosome
• Accession: NZ_CP085821
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Charizard

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF63_RS09205
• Protein ID: WP_000813254.1
• Coordinates: 1889042..1889197 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1888972..1889030 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF63_RS09165	1884073..1884294	-	222	WP_000560208.1	cell division protein FtsZ	-
LJF63_RS09170	1884732..1885253	+	522	WP_000004762.1	super-infection exclusion protein B	-
LJF63_RS09175	1885361..1885516	-	156	WP_085981757.1	DUF1391 family protein	-
LJF63_RS09180	1885901..1886368	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF63_RS23030	1886550..1886597	+	48	Protein_1789	hypothetical protein	-
LJF63_RS09190	1886641..1886970	+	330	WP_001676916.1	DUF977 family protein	-
LJF63_RS09195	1887132..1887686	-	555	WP_001033796.1	hypothetical protein	-
LJF63_RS09200	1887683..1888615	-	933	WP_000556390.1	hypothetical protein	-
-	1888972..1889030	-	59	-	-	Antitoxin
LJF63_RS09205	1889042..1889197	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
LJF63_RS09210	1889488..1889658	+	171	WP_000734094.1	hypothetical protein	-
LJF63_RS09215	1889721..1890320	+	600	WP_000940751.1	DUF1367 family protein	-
LJF63_RS09220	1890320..1890610	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF63_RS09225	1890607..1891143	+	537	WP_000640113.1	DUF1133 family protein	-
LJF63_RS09230	1893314..1893637	+	324	Protein_1798	tellurite/colicin resistance protein	-
LJF63_RS09235	1893631..1893819	+	189	WP_001688615.1	putative holin	-
LJF63_RS09240	1893809..1894090	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1882761..1894632	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T222019 WP_000813254.1 NZ_CP085821:1889042-1889197 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T222019 NZ_CP117656:c53887-53507 [Escherichia albertii]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT222019 NZ_CP085821:c1889030-1888972 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin